SPINAL NERVE ROOT COMPRESSION

被引:75
作者
GARFIN, SR
RYDEVIK, B
LIND, B
MASSIE, J
机构
[1] UNIV CALIF SAN DIEGO,DEPT ORTHOPAED,SAN DIEGO,CA 92103
[2] GOTHENBURG UNIV,DEPT ORTHOPAED,GOTHENBURG,SWEDEN
关键词
Nerve compression; Sciatica; Spinal nerve root;
D O I
10.1097/00007632-199508150-00012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The pathophysiology of sciatica is not completely understood, although our understanding of its causes is increasing. Mechanical alterations combined with inflammatory changes lead to pain. Compression alters nerve root conduction and compromises the nutritional support of spinal nerve roots (through intrinsic and extrinsic vascularity and cerebral spinal fluid percolation). Mechanical forces can lead to intraneural damage and functional changes in nerve roots. Chemical and metabolic effects can create an inflammatory response. Varying causes of inflammation coupled with varying degrees of compression can occur anywhere along the cauda equina or spinal nerve root, including the dorsal root ganglia, and contribute to the pain response and neurologic deficits associated with sciatica.
引用
收藏
页码:1810 / 1820
页数:11
相关论文
共 72 条
[1]  
Arnoldi C.C., Brodsky A.E., Cachoix J., Et al., Lumbar spinal stenosis and nerve root entrapment syndromes-Definition and classification, Clin Orthop, 115, pp. 4-16, (1976)
[2]  
Arvidson B., Distribution of intravenously injected protein tracers in peripheral ganglia of adult mice, Exp Neurol, 63, pp. 388-410, (1979)
[3]  
Blau J.N., Rushworth G., Observations on the blood vessels of the spinal cord and their responses to motor activity, Brain, 81, pp. 354-363, (1958)
[4]  
Breig A., Adverse Mechanical Tension in the Central Nervous System, (1978)
[5]  
Cohen M.S., Wall E.J., Brown R.A., Rydevik B., Garfin S.P., Cauda Equina Anatomy I.I., Extrathecal nerve roots and dorsal root ganglia, Spine, 15, pp. 1248-1251, (1990)
[6]  
Cohen M.S., Wall E.J., Kerber C.W., Abitbol J.J., Garfin S.R., The anatomy of cauda equina on CT scans and MRI, J Bone Joint Surg [Br], 73, pp. 381-384, (1991)
[7]  
Cornefjord M., Takahashi K., Matsui H., Et al., Impairmentof nutritional transport at double level cauda equina compression, Neuro-Orthopaedics, 13, pp. 107-112, (1992)
[8]  
Dahlin L.B., Rydevik B., McLean W.G., Et al., Changes in fast axonal transport during experimental nerve compression at low pressures, Exp Neurol, 84, pp. 29-36, (1984)
[9]  
Delamarter R.B., Bohlman H.H., Bodner D., Et al., Urologic function after experimental cauda equina compression: Cys-tometrograms versus cortical-evoked potentials, Spine, 15, pp. 864-870, (1990)
[10]  
Delamarter R.B., Bohlman H.H., Dodge L.D., Et al., Experimental lumbar spinal stenosis. Analysis of the cortical evoked potentials, microvasculature and histopathology, J Bone Joint Surg [Am], 72, pp. 110-120, (1990)