Clinical experience with rosuvastatin in the management of hyperlipidemia and the reduction of cardiovascular risk

被引：18

作者：

Nicholls, Stephen J. ^{[1
,2
,3
]}

Uno, Kiyoko ^{[1
,2
]}

Kataoka, Yu ^{[1
,2
]}

机构：

[1] Cleveland Clin, Cardiovasc Med & Cell Biol, Cleveland, OH 44195 USA

[2] Cleveland Clin, Ctr Cardiovasc Diagnost & Prevent, Cleveland, OH 44195 USA

[3] Cleveland Clin, Inst Heart & Vasc, Dept Cardiovasc Med, Cleveland, OH 44195 USA

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2011年 / 9卷 / 11期

关键词：

atherosclerosis; cardiovascular disease; clinical trials; lipids; risk factors; rosuvastatin;

D O I：

10.1586/erc.11.145

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

On the basis of large randomized clinical trials, pharmacological antagonists of HMG-CoA reductase (statins) have become increasingly used in clinical practice for the prevention of cardiovascular disease. Rosuvastatin was developed as a potent statin, which appeared to raise levels of HDL-cholesterol, in addition to marked reductions in levels of LDL-cholesterol. These effects on lipids are associated with a beneficial impact of rosuvastatin on progression of various stages of atherosclerosis and cardiovascular outcomes in clinical trials. The clinical experience of rosuvastatin will be reviewed in this article.

引用

页码：1383 / 1390

页数：8

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