RAPID DIAGNOSIS OF MYOCARDIAL-INFARCTION AND REPERFUSION BY ASSAY OF PLASMA ISOFORMS OF CREATINE-KINASE ISOENZYMES

被引：9

作者：

ABENDSCHEIN, DR

机构：

[1] Cardiovascular Division, Washington University School of Medicine, St. Louis, MO

来源：

CLINICAL BIOCHEMISTRY | 1990年 / 23卷 / 05期

关键词：

coronary artery recanalization; creatine kinase isoenzymes; myocardial infarction;

D O I：

10.1016/0009-9120(90)90136-I

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Early, reliable detection of acute myocardial infarction and of coronary artery recanalization, in patients receiving thrombolytic agents, is essential to guide the course of therapy. Because the MM and MB isoenzymes of creatine kinase (CK) released from myocardium, undergo time-dependent removal of carboxyl terminal lysine residues from each monomer during exposure to circulating carboxypeptidase N, plasma profiles of the resulting isoforms are altered promptly and markedly after the release of new tissue isoenzymes. This paper reviews the results of experimental and preliminary clinical studies, showing the potential for rapid diagnosis of myocardial infarction and coronary artery recanalization by analysis of isoforms of CK isoenzymes in plasma. © 1990 The Canadian Society of Clinical Chemists.

引用

页码：399 / 407

页数：9

共 34 条

[1] PROMPT DETECTION OF MYOCARDIAL INJURY BY ASSAY OF CREATINE-KINASE ISOFORMS IN INITIAL PLASMA SAMPLES [J].