VITAMIN-E THERAPY IN RETINOPATHY OF PREMATURITY

被引：22

作者：

MULLER, DPR ^{[1
]}

机构：

[1] INST CHILD HLTH,LONDON WC1N 1EH,ENGLAND

来源：

EYE | 1992年 / 6卷

关键词：

D O I：

10.1038/eye.1992.43

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Vitamin E is a fat soluble antioxidant and as a result it is able to scavenge free radicals derived from oxygen. The premature infant and the retina are likely to be particularly vulnerable to the deleterious effects of these oxygen derived free radicals, and as a result prophylactic vitamin E has been suggested for the management of retinopathy of prematurity (ROP). However, despite numerous trials, prophylactic supplementation with vitamin E remains controversial. This paper will critically review the use of vitamin E in ROP and consider the risk/benefit relationship of such treatment in premature infants.

引用

页码：221 / 225

页数：5

共 46 条

[1]

ALADE SL, 1986, PEDIATRICS, V77, P593

[2]

ARANDA JV, 1986, PEDIATR CLIN N AM, V33, P583

[3]

ARMITAGE P, 1987, STATISTICAL METHODS

[4]

BIERI JG, 1965, P SOC EXP BIOL MED, V120, P554, DOI 10.3181/00379727-120-30588

[5]

Bremer D L, 1986, J Pediatr Ophthalmol Strabismus, V23, P132

[6] IS VITAMIN-E THE ONLY LIPID-SOLUBLE, CHAIN-BREAKING ANTIOXIDANT IN HUMAN-BLOOD PLASMA AND ERYTHROCYTE-MEMBRANES [J].

BURTON, GW ;

JOYCE, A ;

INGOLD, KU .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 221 (01) :281-290

[7]

CENTURY B, 1965, FED PROC, V24, P906

[8] PROTECTIVE EFFECT OF VITAMIN-E (DL-ALPHA-TOCOPHEROL) AGAINST INTRAVENTRICULAR HEMORRHAGE IN PREMATURE BABIES [J].

CHISWICK, ML ;

JOHNSON, M ;

WOODHALL, C ;

GOWLAND, M ;

DAVIES, J ;

TONER, N ;

SIMS, DG .

BMJ-BRITISH MEDICAL JOURNAL, 1983, 287 (6385) :81-84

[9]

FINER NN, 1984, PEDIATRICS, V73, P387

[10]

FINER NN, 1982, LANCET, V1, P1087

← 1 2 3 4 5 →