MALE-FERTILITY AFTER VAPEC-B CHEMOTHERAPY FOR HODGKINS-DISEASE AND NON-HODGKINS-LYMPHOMA

被引：23

作者：

RADFORD, JA ^{[1
]}

CLARK, S ^{[1
]}

CROWTHER, D ^{[1
]}

SHALET, SM ^{[1
]}

机构：

[1] CHRISTIE HOSP,DEPT ENDOCRINOL,MANCHESTER M20 9BX,LANCS,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1994年 / 69卷 / 02期

关键词：

D O I：

10.1038/bjc.1994.69

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Semen analysis was performed in 14 men a median of 13.5 months after completion of VAPEC-B chemotherapy for Hodgkin's disease or non-Hodgkin's lymphoma. Semen from 12 patients contained motile spermatozoa, and in nine cases the count was > 20 million ml(-1). One patient was azoospermic (VAPEC-B followed by pelvic radiotherapy) and another had a count of 21 million ml(-1) but sperm were non-motile. These findings suggest that, in the majority of cases, VAPEC-B chemotherapy does not cause permanent damage to the male germinal epithelium. A more detailed study of gonadal function in males and females before and after treatment with VAPEC-B for Hodgkin's disease is currently in progress.

引用

页码：379 / 381

页数：3

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