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SHAPE SPACE - IS BIOPHARMACEUTICAL DISCOVERY ENTERING A NEW EVOLUTIONARY STAGE
被引:7
作者
:
EDGINGTON, SM
论文数:
0
引用数:
0
h-index:
0
EDGINGTON, SM
机构
:
来源
:
BIO-TECHNOLOGY
|
1993年
/ 11卷
/ 03期
关键词
:
D O I
:
10.1038/nbt0393-285
中图分类号
:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号
:
071005 ;
0836 ;
090102 ;
100705 ;
摘要
:
[No abstract available]
引用
收藏
页码:285 / 289
页数:5
相关论文
共 18 条
[1]
DIRECTED EVOLUTION OF AN RNA ENZYME
BEAUDRY, AA
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
BEAUDRY, AA
JOYCE, GF
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
JOYCE, GF
[J].
SCIENCE,
1992,
257
(5070)
: 635
-
641
[2]
SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN
BOCK, LC
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
BOCK, LC
GRIFFIN, LC
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GRIFFIN, LC
LATHAM, JA
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
LATHAM, JA
VERMAAS, EH
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
VERMAAS, EH
TOOLE, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
TOOLE, JJ
[J].
NATURE,
1992,
355
(6360)
: 564
-
566
[3]
ENCODED COMBINATORIAL CHEMISTRY
BRENNER, S
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
BRENNER, S
LERNER, RA
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
LERNER, RA
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1992,
89
(12)
: 5381
-
5383
[4]
NEW CONCEPTS FOR DEALING WITH THE EVOLUTION OF NUCLEIC-ACIDS
EIGEN, M
论文数:
0
引用数:
0
h-index:
0
EIGEN, M
[J].
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,
1987,
52
: 307
-
320
[5]
SELECTION OF A RIBOZYME THAT FUNCTIONS AS A SUPERIOR TEMPLATE IN A SELF-COPYING REACTION
GREEN, R
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Molecular Biology, Massachusetts General Hospital, Boston
GREEN, R
SZOSTAK, JW
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Molecular Biology, Massachusetts General Hospital, Boston
SZOSTAK, JW
[J].
SCIENCE,
1992,
258
(5090)
: 1910
-
1915
[6]
JOYCE G, 1993, IN PRESS PURE APPLIE
[7]
Kaufmann S. A., 1993, ORIGINS ORDER SELF O
[8]
IDENTIFICATION OF NOVEL PEPTIDE ANTAGONISTS FOR GPIIB/IIIA FROM A CONFORMATIONALLY CONSTRAINED PHAGE PEPTIDE LIBRARY
ONEIL, KT
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
ONEIL, KT
HOESS, RH
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
HOESS, RH
JACKSON, SA
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
JACKSON, SA
RAMACHANDRAN, NS
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
RAMACHANDRAN, NS
MOUSA, SA
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
MOUSA, SA
DEGRADO, WF
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DEGRADO, WF
[J].
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,
1992,
14
(04)
: 509
-
515
[9]
THEORETICAL-STUDIES OF CLONAL SELECTION - MINIMAL ANTIBODY REPERTOIRE SIZE AND RELIABILITY OF SELF-NON-SELF DISCRIMINATION
PERELSON, AS
论文数:
0
引用数:
0
h-index:
0
机构:
BROWN UNIV, PROVIDENCE, RI 02912 USA
PERELSON, AS
OSTER, GF
论文数:
0
引用数:
0
h-index:
0
机构:
BROWN UNIV, PROVIDENCE, RI 02912 USA
OSTER, GF
[J].
JOURNAL OF THEORETICAL BIOLOGY,
1979,
81
(04)
: 645
-
670
[10]
AMINOACYL ESTERASE-ACTIVITY OF THE TETRAHYMENA RIBOZYME
PICCIRILLI, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
PICCIRILLI, JA
MCCONNELL, TS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
MCCONNELL, TS
ZAUG, AJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
ZAUG, AJ
NOLLER, HF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
NOLLER, HF
CECH, TR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
CECH, TR
[J].
SCIENCE,
1992,
256
(5062)
: 1420
-
1424
←
1
2
→
共 18 条
[1]
DIRECTED EVOLUTION OF AN RNA ENZYME
BEAUDRY, AA
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
BEAUDRY, AA
JOYCE, GF
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
JOYCE, GF
[J].
SCIENCE,
1992,
257
(5070)
: 635
-
641
[2]
SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN
BOCK, LC
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
BOCK, LC
GRIFFIN, LC
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GRIFFIN, LC
LATHAM, JA
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
LATHAM, JA
VERMAAS, EH
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
VERMAAS, EH
TOOLE, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
GILEAD SCI INC,346 LAKESIDE DR,FOSTER CITY,CA 94404
TOOLE, JJ
[J].
NATURE,
1992,
355
(6360)
: 564
-
566
[3]
ENCODED COMBINATORIAL CHEMISTRY
BRENNER, S
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
BRENNER, S
LERNER, RA
论文数:
0
引用数:
0
h-index:
0
机构:
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
SCRIPPS RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
LERNER, RA
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1992,
89
(12)
: 5381
-
5383
[4]
NEW CONCEPTS FOR DEALING WITH THE EVOLUTION OF NUCLEIC-ACIDS
EIGEN, M
论文数:
0
引用数:
0
h-index:
0
EIGEN, M
[J].
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY,
1987,
52
: 307
-
320
[5]
SELECTION OF A RIBOZYME THAT FUNCTIONS AS A SUPERIOR TEMPLATE IN A SELF-COPYING REACTION
GREEN, R
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Molecular Biology, Massachusetts General Hospital, Boston
GREEN, R
SZOSTAK, JW
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Molecular Biology, Massachusetts General Hospital, Boston
SZOSTAK, JW
[J].
SCIENCE,
1992,
258
(5090)
: 1910
-
1915
[6]
JOYCE G, 1993, IN PRESS PURE APPLIE
[7]
Kaufmann S. A., 1993, ORIGINS ORDER SELF O
[8]
IDENTIFICATION OF NOVEL PEPTIDE ANTAGONISTS FOR GPIIB/IIIA FROM A CONFORMATIONALLY CONSTRAINED PHAGE PEPTIDE LIBRARY
ONEIL, KT
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
ONEIL, KT
HOESS, RH
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
HOESS, RH
JACKSON, SA
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
JACKSON, SA
RAMACHANDRAN, NS
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
RAMACHANDRAN, NS
MOUSA, SA
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
MOUSA, SA
DEGRADO, WF
论文数:
0
引用数:
0
h-index:
0
机构:
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DUPONT MERCK PHARMACEUT CO, EXPTL STN, BLDG 328, ROOM 127, POB 80328, WILMINGTON, DE 19880 USA
DEGRADO, WF
[J].
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,
1992,
14
(04)
: 509
-
515
[9]
THEORETICAL-STUDIES OF CLONAL SELECTION - MINIMAL ANTIBODY REPERTOIRE SIZE AND RELIABILITY OF SELF-NON-SELF DISCRIMINATION
PERELSON, AS
论文数:
0
引用数:
0
h-index:
0
机构:
BROWN UNIV, PROVIDENCE, RI 02912 USA
PERELSON, AS
OSTER, GF
论文数:
0
引用数:
0
h-index:
0
机构:
BROWN UNIV, PROVIDENCE, RI 02912 USA
OSTER, GF
[J].
JOURNAL OF THEORETICAL BIOLOGY,
1979,
81
(04)
: 645
-
670
[10]
AMINOACYL ESTERASE-ACTIVITY OF THE TETRAHYMENA RIBOZYME
PICCIRILLI, JA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
PICCIRILLI, JA
MCCONNELL, TS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
MCCONNELL, TS
ZAUG, AJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
ZAUG, AJ
NOLLER, HF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
NOLLER, HF
CECH, TR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV COLORADO,HOWARD HUGHES MED INST,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
CECH, TR
[J].
SCIENCE,
1992,
256
(5062)
: 1420
-
1424
←
1
2
→