HELICOBACTER-PYLORI AND GASTROESOPHAGEAL REFLUX DISEASE - A PROSPECTIVE-STUDY

被引：72

作者：

OCONNOR, HJ

CUNNANE, K

机构：

[1] Department of Medicine, General Hospital, Tullamore, Co., Offaly

[2] Departments of Pathology, General Hospital, Tullamore, Co., Offaly

来源：

IRISH JOURNAL OF MEDICAL SCIENCE | 1994年 / 163卷 / 08期

关键词：

D O I：

10.1007/BF02942830

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a prospective evaluation of the relationship between Helicobacter pylori infection an gastro-oesophageal reflux disease (GORD), 93 consecutive patients (47 female: 46 male: mean age, 46 years: range 13-93) with symptoms and endoscopic evidence of GORD were studied. A total of 50 patients (54%) were H. pylori-positive on gastric antral biopsies. No significant correlation was detected between H. pylori status and grade of Gesophagitis. The prevalence of H. pylori infection showed a gradual increase with age. Of 64 patients with a hiatal hernia, 28 (44%) had histological evidence of H. pylori infection of the hernia mucosa; 27 of these patients (96%) had associated H. pylori in the gastric antrum. Of the 36 patients whose hiatal hernia was H. pylori-negative, only 6 (17%) had antral H. pylori (P<0.001). Of the 8 patients found to have Barrett's oesophagus, only 1 had H. pylori detected on the Barrett's mucosa. Our results do not support the presence of a significant association between H. pylori infection and GORD.

引用

页码：369 / 373

页数：5

共 23 条

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