HISTOCHEMISTRY OF NITRIC-OXIDE SYNTHASE IN THE NERVOUS-SYSTEM

被引:3
作者
BLOTTNER, D
GROZDANOVIC, Z
GOSSRAU, R
机构
来源
HISTOCHEMICAL JOURNAL | 1995年 / 27卷 / 10期
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中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Nitric oxide synthase, which generates the physiological messenger molecule nitric oxide, and its associated NADPH diaphorase (NADPHd) activity are distributed throughout selective neuronal populations of the central and peripheral nervous system. Considerable evidence has been accumulated to indicate that NADPHd activity labels cells lacking neuronal nitric oxide synthase, i.e., the specificity of the reaction has to be considered for the reliable detection of the enzyme in neuronal but also non-neuronal tissue. In the present review, critical aspects of nitric oxide synthase visualization in neurones, using its NADPHd activity, are discussed. Furthermore, the organization of the central and peripheral nitric oxide synthase-containing neuronal systems is described. Nitric oxide synthase is present in local cortical and striatal neurones, hypothalamic magnocellular neurones, mesopontine cholinergic neurones, cerebellar intemeurones, preganglionic sympathetic and parasympathetic neurones, neurones in parasympathetic autonomic and enteric ganglia and primary viscero-afferent neurones. Finally, injury-related alterations in nitric oxide synthase activity are briefly outlined. In this respect, the histochemistry of nitric oxide synthase may represent a valuable marker for neurochemical, if not structural, alterations observed in neural diseases, regeneration and transplantation.
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页码:785 / 811
页数:27
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共 269 条
[1]   COLOCALIZATION OF NITRIC-OXIDE SYNTHASE AND NADPH-DIAPHORASE IN RAT ADRENAL-GLAND [J].
AFEWORK, M ;
TOMLINSON, A ;
BELAI, A ;
BURNSTOCK, G .
NEUROREPORT, 1992, 3 (10) :893-896
[2]   HISTOCHEMICAL-LOCALIZATION OF NITRIC-OXIDE SYNTHASE IN RAT ENTERIC NERVOUS-SYSTEM [J].
AIMI, Y ;
KIMURA, H ;
KINOSHITA, T ;
MINAMI, Y ;
FUJIMURA, M ;
VINCENT, SR .
NEUROSCIENCE, 1993, 53 (02) :553-560
[3]   LOCALIZATION OF NADPH-DIAPHORASE-CONTAINING NEURONS IN SENSORY GANGLIA OF THE RAT [J].
AIMI, Y ;
FUJIMURA, M ;
VINCENT, SR ;
KIMURA, H .
JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 306 (03) :382-392
[4]   CABP D-28K AND NADPH-DIAPHORASE COEXISTENCE IN THE MAGNOCELLULAR NEUROSECRETORY NUCLEI [J].
ALONSO, JR ;
SANCHEZ, F ;
AREVALO, R ;
CARRETERO, J ;
AIJON, J ;
VAZQUEZ, R .
NEUROREPORT, 1992, 3 (03) :249-252
[5]   NADPH DIAPHORASE-POSITIVE NEURONS IN THE RAT SPINAL-CORD INCLUDE A SUBPOPULATION OF AUTONOMIC PREGANGLIONIC NEURONS [J].
ANDERSON, CR .
NEUROSCIENCE LETTERS, 1992, 139 (02) :280-284
[6]   THE DISTRIBUTION OF NITRIC-OXIDE SYNTHASE-CONTAINING AUTONOMIC PREGANGLIONIC TERMINALS IN THE RAT [J].
ANDERSON, CR ;
EDWARDS, SL ;
FURNESS, JB ;
BREDT, DS ;
SNYDER, SH .
BRAIN RESEARCH, 1993, 614 (1-2) :78-85
[7]   PREDOMINANT LOCALIZATION IN GLIAL-CELLS OF FREE L-ARGININE - IMMUNOCYTOCHEMICAL EVIDENCE [J].
AOKI, E ;
SEMBA, R ;
MIKOSHIBA, K ;
KASHIWAMATA, S .
BRAIN RESEARCH, 1991, 547 (02) :190-192
[8]   DISTRIBUTION AND MORPHOLOGICAL FEATURES OF NITRERGIC NEURONS IN THE PORCINE LARGE-INTESTINE [J].
BARBIERS, M ;
TIMMERMANS, JP ;
SCHEUERMANN, DW ;
ADRIAENSEN, D ;
MAYER, B ;
DEGROODTLASSEEL, MHA .
HISTOCHEMISTRY, 1993, 100 (01) :27-34
[9]   REPLICATION OF THE NEUROCHEMICAL CHARACTERISTICS OF HUNTINGTONS-DISEASE BY QUINOLINIC ACID [J].
BEAL, MF ;
KOWALL, NW ;
ELLISON, DW ;
MAZUREK, MF ;
SWARTZ, KJ ;
MARTIN, JB .
NATURE, 1986, 321 (6066) :168-171
[10]   EVIDENCE FOR COEXISTENCE OF ATP AND NITRIC-OXIDE IN NONADRENERGIC, NONCHOLINERGIC (NANC) INHIBITORY NEURONS IN THE RAT ILEUM, COLON AND ANOCOCCYGEUS MUSCLE [J].
BELAI, A ;
BURNSTOCK, G .
CELL AND TISSUE RESEARCH, 1994, 278 (01) :197-200