SYNTHESIS OF CARBACEPHEM ANTIBIOTICS - SYNTHESIS VIA DIECKMANN REACTION USING PHENYL-ESTERS TO DIRECT THE REGIOSELECTIVITY OF THE CYCLIZATION

被引:24
作者
JACKSON, BG [1 ]
GARDNER, JP [1 ]
HEATH, PC [1 ]
机构
[1] ELI LILLY INT CORP,LILLY RES LAB,LILLY CORP CTR,INDIANAPOLIS,IN 46285
关键词
D O I
10.1016/S0040-4039(00)97052-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
β-Ketoesters useful for elaboration to carbacephems were synthesized from a variety of enantiomerically pure diesters. Use of phenyl esters to direct the regioselectivity was demonstrated. © 1990.
引用
收藏
页码:6317 / 6320
页数:4
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