INHIBITORY EFFECTS OF RECOMBINANT HUMAN CYSTATIN-C ON HUMAN CORONAVIRUSES

被引：61

作者：

COLLINS, AR ^{[1
]}

GRUBB, A ^{[1
]}

机构：

[1] UNIV LUND HOSP,DEPT CLIN CHEM,S-22185 LUND,SWEDEN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 11期

关键词：

D O I：

10.1128/AAC.35.11.2444

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cystatin C, a potent inhibitor of cysteine proteases such as papain and cathepsin B, was examined for its effect on human coronaviruses OC43 and 229e. Both viruses were > 99% inhibited by 0.1 mM inhibitor. Endpoint titrations showed that inhibiting activity paralleled that of leupeptin, a serine and cysteine protease inhibitor, and indicated that 1 to 2-mu-M inhibitor, slightly above physiologic levels, was effective.

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页码：2444 / 2446

页数：3

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