SETUP FOR THE DETERMINATION OF THE PHOTODYNAMIC ACTIVITY OF DYES ON THE BASIS OF SCATTERING MEASUREMENTS

被引：2

作者：

KONIG, K

AUCHTER, S

机构：

[1] Institut für Lasertechnologien in der Medizin an der Universität Ulm, D-7900 Ulm

来源：

BIOMEDIZINISCHE TECHNIK | 1991年 / 36卷 / 09期

关键词：

PHOTODYNAMIC ACTIVITY; PORPHYRIN; PHOTOPRODUCT; ACTION SPECTRUM; SCATTER MEASUREMENT;

D O I：

10.1515/bmte.1991.36.9.201

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An experimental setup for the determination of the photodynamic activity of dyes on the basis of scattering measurements is described. With its aid, photochemically induced morphological changes and the process of cell lysis can be registered, and action spectra measured by varying the irradiation wavelength. Different photoproducts of the photosensitzer hematoporphyrin derivative (HPD) were tested in human erythrocyte suspensions. The photodynamic activity of these products was found to depend on absorption behavior, but is lower than that of HPD.

引用

页码：201 / 205

页数：5

共 12 条

[1]

Dietel W., 1990, Lasers in the Life Sciences, V3, P197

[2]

DOIRON DR, 1983, PORPHYRIN LOCALIZATI

[3] PHOTODYNAMIC EFFECTS OF PROTOPORPHYRIN ON HUMAN ERYTHROCYTES - NATURE OF CROSS-LINKING OF MEMBRANE PROTEINS [J].