FACILITATION OF DIPHOSPHATE GROUP ELIMINATION FROM GERANYL DIPHOSPHATE BY MAGNESIUM-ION CHELATION IN CYCLIC MONOTERPENOID BIOSYNTHESIS

被引：6

作者：

ITO, DI ^{[1
]}

IZUMI, S ^{[1
]}

HIRATA, T ^{[1
]}

SUGA, T ^{[1
]}

机构：

[1] HIROSHIMA UNIV,FAC SCI,DEPT CHEM,HIROSHIMA 724,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 01期

关键词：

D O I：

10.1039/p19920000037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The role of divalent metal ions in the biosynthesis of cyclic monoterpenoids has been investigated by an analysis of the P-31 and C-13 NMR spectra of geranyl diphosphate (GPP) in the presence and in the absence of Mg2+. This study revealed that Mg2+ binds to the diphosphate moiety of GPP in the ratio of 1:1, equidistantly from both phosphorus atoms, and that Mg2+ chelation weakens the C(1)-O(5) bond of GPP, facilitating elimination of the diphosphate group.

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页码：37 / 39

页数：3

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