ANTI-BOVINE VIRAL DIARRHEA VIRUS-ANTIBODIES IN ADULT ZAMBIAN PATIENTS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS

被引：6

作者：

GIANGASPERO, M ^{[1
]}

VACIRCA, G ^{[1
]}

MORGAN, D ^{[1
]}

BABOO, KS ^{[1
]}

LUO, NP ^{[1
]}

DUPONT, HL ^{[1
]}

ZUMLA, A ^{[1
]}

机构：

[1] UNIV ZAMBIA,SCH MED,LUSAKA,ZAMBIA

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 1993年 / 4卷 / 05期

关键词：

BOVINE VIRAL DIARRHEA VIRUS; AFRICA; HUMAN IMMUNODEFICIENCY VIRUS; DIARRHEA;

D O I：

10.1177/095646249300400510

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bovine viral diarrhoea (BVD) virus is a cosmopolitan pestivirus of animals which is associated with diarrhoea, immunosuppression and synergy with other pathogens. This study was conducted to establish the prevalence of anti-BVD virus antibodies in healthy Zambian adults and those with asymptomatic and symptomatic HIV disease. Sera from 1159 adults were tested for anti-BVD virus antibodies using the indirect immunofluorescence test and the confirmatory Western blot. Of the 1159 sera examined, 180 (15.5%) showed significantly elevated titres of anti-BVD antibodies. These included 70 out of 477 (14.7%) HIV-negative healthy adults; 73 out of 480 (15.2%) of HIV-positive asymptomatic individuals; 23 out of 129 (17.8%) HIV-seropositive patients with associated illnesses excluding diarrhoea; and 14 out of 73 (19.2%) of HIV-seropositive patients with chronic diarrhoea. HIV-seropositive patients with chronic diarrhoea or associated illnesses appear to have significantly increased seroprevalence of anti-BVD virus antibodies (P = > 0.01). The mechanism of interaction between BVD virus and HIV infections and the synergistic effects with other opportunistic pathogens in humans requires definition.

引用

页码：300 / 302

页数：3

共 19 条

[1] Castrucci G., Infezione da virus degli animali domestici, (1978)
[2] Bolin J.R., McClurkin A.W., Coria M.F., Frequency of persistent BVD virus infection in selected cattle herds, Am J Vet Res, 46, pp. 2378-2385, (1985)
[3] Doyle W.L.G., Heuschele W.P., BVD virus infection in captive exotic ruminants, JAVMA, 183, (1983)
[4] Heuschele W.P., New perspectives on the epidemiology of BVD-MD virus, Bovine Pract, 13, pp. 51-53, (1978)
[5] Done J.T., BVD-MD virus. Pathogenicity for the foetal calf following maternal infection, Vet Record, 106, pp. 473-479, (1980)
[6] Giangespero M., Wellermans G., Vanapdenbosch E., Belloli A., Verhulst A., Bovine viral Diarrhoea, Lancet, ii, (1988)
[7] Giangaspero M., Blondeel H., Bear J., Alders R., Morgan D., Epidemiological survey on Bovine Viral Diarrhoea virus in Zambian cattle, Zimbabwe Vet J, 22, pp. 57-63, (1991)
[8] Pocock D.H., Howard C.J., Clarke M.C., Brownlie J., Molecular variation between BVD virus isolates. AFRC institute for research on animal diseases, Arch Virol, 94, pp. 43-51, (1987)
[9] Roeder P.L., Drewt W., BVD-MD of cattle: A late sequel to fetal infection, Vet Rec, 114, (1984)
[10] Pagnini P., Martone P., Ricerch sulla resistenza del BVD virus agli agenti fisici e nell'aqua, Acta Med Vet, 30, pp. 277-284, (1984)

← 1 2 →