IDENTIFICATION OF HEPATITIS-C VIRUS GENOTYPES AMONG HOSPITALIZED-PATIENTS IN BRITISH-COLUMBIA, CANADA

被引：10

作者：

ALTAMIRANO, M

DELANEY, A

WONG, A

MAROSTENMAKI, J

PI, D

机构：

[1] UNIV BRITISH COLUMBIA,BIOMED RES CTR,VANCOUVER,BC V5Z 1M9,CANADA

[2] VANCOUVER GEN HOSP,VANCOUVER,BC,CANADA

[3] CANADIAN RED CROSS SOC,VANCOUVER BLOOD CTR,VANCOUVER,BC,CANADA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 04期

关键词：

D O I：

10.1093/infdis/171.4.1034

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The distribution pattern of hepatitis C virus (HCV) genotypes among patients from British Columbia has been investigated by reverse transcription polymerase chain reaction (PCR) amplification of the 5' noncoding region (NCR) and direct DNA sequencing of the PCR product. The sequence data obtained from the British Columbia isolates were compared with HCV sequences for the NCR obtained from GenBank for the construction of a phylogenetic tree using the GDE program, version 2.2. The data show that in British Columbia there are 7 subtypes distributed among major genotypes 1, 2, and 3, The study also shows a new subtype of genotype 1 that represents 29% of the analyzed cases.

引用

页码：1034 / 1038

页数：5

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