THE EFFECT OF ENDOTOXIN ON GASTROINTESTINAL TRANSIT-TIME AND INTESTINAL PERMEABILITY

被引：20

作者：

JENNINGS, G

LUNN, PG

ELIA, M

机构：

[1] Dunn Nutrition Laboratory, Cambridge, CB4 1XJ, Downham's Lane, Milton Road

来源：

CLINICAL NUTRITION | 1995年 / 14卷 / 01期

关键词：

D O I：

10.1016/S0261-5614(06)80008-7

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Acute changes in gastrointestinal transit time, creatinine clearance and dual sugar (lactulose/mannitol) intestinal permeability have been assessed following endotoxin administration (E. coli 0111:B4, phenol extract) to 6 week old rats. Monitoring the progress of orally administered Cr-51-EDTA through the digestive tract showed that, compared to saline injected controls, stomach emptying was considerably delayed in endotoxin treated animals (t 1/2 = 26 +/- 2 vs 162 +/- 20 min (p < 0.01), but transit time through the smart intestine was not significantly altered (81 +/- 17 v 93 +/- 29 min). Intestinal permeability assessed by the ratio of lactulose to mannitol excretion in urine was higher in endotoxin compared to saline injected rats, 1.01 +/- 0.08 vs 0.60 +/- 0.04 (p < 0.01). After correcting the individual sugar excretion to take into account the amount of marker available to the small intestine for absorption during the test period, it was concluded that endotoxin treatment was associated with increased lactulose uptake but no change in mannitol absorption. The study also shows that endotoxaemia, uncomplicated by drug administration or other therapeutic manoeuvres, can markedly delay gastric emptying, which is associated with intolerance to oral or nasogastric feeding.

引用

页码：35 / 41

页数：7

共 19 条

[1]

J.E., Total Parenteral Nutrition, (1991)

[2]

Walker, Povanznik, Disruption of the permeability barrier between intestinal epithelial cells by lethal doses of endotoxin, Infect Immun, 21, pp. 655-658, (1978)

[3]

Deitch, Berg, Specian, Endotoxin promotes the translocation of bacteria from the gut, Arch Surg, 122, pp. 185-190, (1987)

[4]

Deitch, Winterton, Li, Berg, The gut as a portal of entry for bacteria: Role of protein malnutrition, Ann Surg, 205, pp. 681-692, (1987)

[5]

Sori, Rush, Lysz, Smith, Machiedo, The gut as a source of sepsis after hemorrhagic shock, Am J Surg, 155, pp. 187-192, (1988)

[6]

Munster, Smith-Meek, Dickerson, Winchurch, Translocation: Incidental phenomenon or true pathology, Ann Surg, 218, pp. 321-327, (1993)

[7]

Isolauri, Juntunen, Wiren, Vaurinen, Koirvula, Intestinal permeability changes in acute gastroenteritis: effects of clinical factors and nutritional management, J Pediatr Gastroenterol Nutr, 8, pp. 466-473, (1989)

[8]

Elia, Northrop-Clewes, Lunn, Goren, Intestinal permeability in man effects of acute systemic infections, Clinical Nutrition, 10, pp. 67-80, (1991)

[9]

Jennings, Lunn, Northrop-Clewes, Elia, The effect of endotoxin and turpentine administration on intestinal permeability in the rat, Clin Nutr, 10, pp. 43-48, (1991)

[10]

Fabiny, Ertingshausen, Automated reaction-rate method for determination of serum creatinine with the centrifichem, Clin Chim Acta, 17, pp. 696-700, (1971)

← 1 2 →