POTASSIUM, RUBIDIUM, AND 4-AMINOPYRIDINE EFFECTS ON THE CIRCADIAN RUNNING RHYTHM IN THE HAMSTER

被引：2

作者：

KLEMFUSS, H ^{[1
]}

KRIPKE, DF ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,SAN DIEGO,CA 92103

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 47卷 / 03期

关键词：

POTASSIUM; RUBIDIUM; 4-AMINOPYRIDINE; ACTIVITY; CHANNEL BLOCKER; CIRCADIAN;

D O I：

10.1016/0091-3057(94)90136-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The period of the circadian rhythm of wheel-running was shortened when golden hamsters were given supplemental dietary potassium or rubidium for two weeks. Treatment with 4-aminopyridine, a potassium channel blocker, significantly increased circadian period. These period changes (0.17 h for potassium treatment, 0.14 h for rubidium, and 0.07 h for 4-aminopyridine) support previous data indicating that potassium is a component of the mammalian biological clock mechanism.

引用

页码：409 / 412

页数：4

共 34 条

[1] INVIVO EVIDENCE FOR A CIRCADIAN-RHYTHM IN MEMBRANES OF GONYAULAX [J].

ADAMICH, M ;

LARIS, PC ;

SWEENEY, BM .

NATURE, 1976, 261 (5561) :583-585

[2] EFFECTS OF 4-AMINOPYRIDINE ON THE TURNOVER OF MONO-AMINES IN THE CENTRAL NERVOUS-SYSTEM OF THE RAT [J].

ANDEN, NE ;

LEANDER, S .

JOURNAL OF NEURAL TRANSMISSION, 1979, 44 (1-2) :1-12

[3]

BAUER KTT, 1993, CHRONOBIOLOGY CHRONO, P450

[4]

BIJAK M, 1989, FOLIA BIOL-KRAKOW, V37, P3

[5] STABILITY OF POTASSIUM CONTENT OF CEREBROSPINAL FLUID AND BRAIN [J].

BRADBURY, MW ;

KLEEMAN, CR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1967, 213 (02) :519-+

[6] MODEL FOR MOLECULAR-BASIS OF CIRCADIAN-RHYTHMS INVOLVING MONO-VALENT ION-MEDIATED TRANSLATIONAL CONTROL [J].

BURGOYNE, RD .

FEBS LETTERS, 1978, 94 (01) :17-19

[7] POTASSIUM AND RUBIDIUM PERMEABILITY AND POTASSIUM CONDUCTANCE OF THE BETA-CELL MEMBRANE IN MOUSE ISLETS OF LANGERHANS [J].

DAWSON, CM ;

CROGHAN, PC ;

SCOTT, AM ;

BANGHAM, JA .

QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1986, 71 (02) :205-222

[8]

DRENNAN MD, 1992, 3RD P M SOC RES BIOL, P106

[9] CIRCADIAN VASOPRESSIN RELEASE FROM PERIFUSED RAT SUPRACHIASMATIC EXPLANTS INVITRO - EFFECTS OF ACUTE STIMULATION [J].

EARNEST, DJ ;

SLADEK, CD .

BRAIN RESEARCH, 1987, 422 (02) :398-402

[10] EFFECT OF RBCL ON THE CIRCADIAN-RHYTHM OF LOCOMOTOR-ACTIVITY IN THE COCKROACH LEUCOPHAEA-MADERAE [J].

ENGELMANN, W ;

CASPER, H .

JOURNAL OF INTERDISCIPLINARY CYCLE RESEARCH, 1984, 15 (01) :17-22

← 1 2 3 4 →