THE SUPPRESSION OF AGE-RELATED ACCUMULATION OF LIPID PEROXIDES IN RAT-BRAIN BY ADMINISTRATION OF ROOIBOS TEA (ASPALATHUS-LINEARIS)

被引：48

作者：

INANAMI, O

ASANUMA, T

INUKAI, N

JIN, T

SHIMOKAWA, S

KASAI, N

NAKANO, M

SATO, F

KUWABARA, M

机构：

[1] HOKKAIDO UNIV,FAC VET MED,SAPPORO,HOKKAIDO 060,JAPAN

[2] IWATE UNIV,FAC AGR,MORIOKA,IWATE 020,JAPAN

[3] HOKKAIDO UNIV,INST ELECT SCI,SAPPORO,HOKKAIDO 060,JAPAN

[4] HOKKAIDO UNIV,FAC ENGN,SAPPORO,HOKKAIDO 060,JAPAN

[5] TOHOKU UNIV,SCH MED,SENDAI,MIYAGI 981,JAPAN

[6] AICHI MED UNIV,INST MED SCI AGING,NAGAKUTE,AICHI 48011,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 196卷 / 1-2期

关键词：

AGING; ANTIOXIDANTS; LIPID PEROXIDES; MAGNETIC RESONANCE IMAGING; RAT; ROOIBOS TEA (ASPALATHUS LINEARIS);

D O I：

10.1016/0304-3940(95)11853-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The protective effects of Rooibos tea (RT), Aspalathus linearis, against damage to the central nervous system (CNS) accompanying aging were examined by both the thiobarbituric acid reaction (TBA) and magnetic resonance imaging (MRI) methods in brains of chronically RT-treated rats. Ad libitum administration of RT was begun with 3-month-old Wistar female rats and continued for 21 months, The contents of TBA reactive substances (TBARS) in the frontal cortex, occipital cortex, hippocampus and cerebellum in 24-month-old rats after administration with water were significantly higher than those in young rats (5 weeks old), However, no significant increase of TBARS was observed in RT-administered aged rats. When MR images of the brains of 24-month-old rats with and without RT as well as 5-week-old rats were taken, a decrease of the signal intensity was observed in the cerebral cortex, hippocampus and cerebellum in MR images of aged rats without RT, whereas little change of the signal intensity was observed in MR images of the same regions of 24-month-old rats treated with RT, whose images were similar to those of young rats. These observations suggested that (1) the age-related accumulation of lipid peroxides in the brain was closely related to the morphological changes observed by MRI, and (2) chronic RT-administration prevented age-related accumulation of lipid peroxides in several regions of rat brain.

引用

页码：85 / 88

页数：4

共 22 条

[1] REVERSAL OF AGE-RELATED INCREASE IN BRAIN PROTEIN OXIDATION, DECREASE IN ENZYME-ACTIVITY, AND LOSS IN TEMPORAL AND SPATIAL MEMORY BY CHRONIC ADMINISTRATION OF THE SPIN-TRAPPING COMPOUND N-TERT-BUTYL-ALPHA-PHENYLNITRONE [J].

CARNEY, JM ;

STARKEREED, PE ;

OLIVER, CN ;

LANDUM, RW ;

CHENG, MS ;

WU, JF ;

FLOYD, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3633-3636

[2]

FLOYD RA, 1991, PERSPECTIVES, V13, P1597

[3] VOLATILE COMPONENTS OF ROOIBOS TEA (ASPALATHUS-LINEARIS) [J].

HABU, T ;

FLATH, RA ;

MON, TR ;

MORTON, JF .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1985, 33 (02) :249-254

[4] AGING - A THEORY BASED ON FREE-RADICAL AND RADIATION-CHEMISTRY [J].

HARMAN, D .

JOURNALS OF GERONTOLOGY, 1956, 11 (03) :298-300

[5] THE AGING PROCESS [J].

HARMAN, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :7124-7128

[6]

ITO A, 1992, INT CONGR SER, V998, P827

[7]

KUWABARA M, 1994, J VET MED SCI, V55, P933

[8]

MIQUEL J, 1977, FREE RADICAL BIO MED, P133

[9]

NAKANO M, 1994, ROOIBOS TEA

[10] LIPID PEROXIDES IN BRAIN DURING AGING AND VITAMIN-E-DEFICIENCY - POSSIBLE RELATIONS TO CHANGES IN NEUROTRANSMITTER INDEXES [J].

NODA, Y ;

MCGEER, PL ;

MCGEER, EG .

NEUROBIOLOGY OF AGING, 1982, 3 (03) :173-178

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