Activated platelets and atherosclerosis

被引：40

作者：

Aukrust, Pal ^{[1
,2
,3
]}

Halvorsen, Bente ^{[1
,3
]}

Ueland, Thor ^{[1
,4
]}

Michelsen, Annika E. ^{[1
]}

Skjelland, Mona ^{[5
]}

Gullestad, Lars ^{[3
,6
]}

Yndestad, Arne ^{[1
]}

Otterdal, Kari ^{[1
,3
]}

机构：

[1] Oslo Univ Hosp Rikshospitalet, Res Inst Internal Med, N-0027 Oslo, Norway

[2] Oslo Univ Hosp Rikshospitalet, Sect Clin Immunol & Infect Dis, Oslo, Norway

[3] Univ Oslo, Fac Med, Oslo, Norway

[4] Oslo Univ Hosp Rikshospitalet, Dept Endocrinol, Oslo, Norway

[5] Oslo Univ Hosp Rikshospitalet, Dept Neurol, Oslo, Norway

[6] Oslo Univ Hosp Rikshospitalet, Dept Cardiol, Oslo, Norway

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2010年 / 8卷 / 09期

关键词：

atherosclerosis; chemokines; cytokines; inflammation; platelets;

D O I：

10.1586/ERC.10.92

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several studies suggest an important role for platelets in atherogenesis, not only as mediators of thrombus formation, but also as inducers of inflammation. Several lines of evidence indicate that platelets are potent inflammatory cells that induce inflammatory responses in adjacent cells such as leukocytes and endothelial cells. Platelets may also themselves respond to inflammatory mediators produced by these neighboring cells. These platelet-mediated inflammatory pathways contribute to atherogenesis in both the early and late stage of the process. The bidirectional interaction between platelets and other cells may also be involved in the nonresolving inflammation characterizing atherosclerosis. In patients with atherosclerotic disorders, platelet-mediated inflammation appears to be operating in spite of the wide use of platelet-inhibiting drugs. This underscores the need for new therapeutic tools that more specifically target the pathways in platelet-mediated inflammation.

引用

页码：1297 / 1307

页数：11

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