RAPID DETECTION OF CHROMOSOME-16 INVERSION IN ACUTE NONLYMPHOCYTIC LEUKEMIA, SUBTYPE M4 - REGIONAL LOCALIZATION OF THE BREAKPOINT IN 16P

被引：61

作者：

DAUWERSE, JG ^{[1
]}

KIEVITS, T ^{[1
]}

BEVERSTOCK, GC ^{[1
]}

VANDERKEUR, D ^{[1
]}

SMIT, E ^{[1
]}

WESSELS, HW ^{[1
]}

HAGEMEIJER, A ^{[1
]}

PEARSON, PL ^{[1
]}

VANOMMEN, GJB ^{[1
]}

BREUNING, MH ^{[1
]}

机构：

[1] ERASMUS UNIV,DEPT CELL BIOL & GENET,3000 DR ROTTERDAM,NETHERLANDS

来源：

CYTOGENETICS AND CELL GENETICS | 1990年 / 53卷 / 2-3期

关键词：

D O I：

10.1159/000132911

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The pericentric inversion of chromosome 16 characteristic tor acute nonlymphocytic leukemia, subtype M4, was detected in five patients b\ means of nonradioactive in situ hybridization of complete cosmids. Hirst, five cosmids situated along the short arm of chromosome 16 were used to map the breakpoint of the inversion distal lo the rare folale-scnsilivc fragile site 1 KAI6A. I hen. ihe use of i wo cosmids on either side of the breakpoint, combined with a probe specific for thcccntromcnc region of chromosome 16. readily detected the inversion, even in poor meta-phase spreads. © 1990 S. Karger AG, Basel.

引用

页码：126 / &

共 17 条

[1]

ARTHUR DC, 1983, BLOOD, V61, P994

[2]

BREUNING MH, 1989, CYTOGENET CELL GENET, V51, P969

[3]

CALLEN DF, 1986, ANN GENET-PARIS, V29, P235

[4] COSMID VECTOR PCPG AND PLASMID VECTOR PKNUN1, AND THEIR USE FOR CLONING DNA-SEQUENCES ADJACENT TO SITES FOR RARE CUTTING RESTRICTION ENDONUCLEASES [J].

DAUWERSE, HG ;

VANOMMEN, GB ;

BREUNING, MH ;

PEARSON, PL .

NUCLEIC ACIDS RESEARCH, 1989, 17 (09) :3603-3603

[5] ABNORMALITIES OF CHROMOSOME-16 IN ASSOCIATION WITH ACUTE MYELOMONOCYTIC LEUKEMIA AND DYSPLASTIC BONE-MARROW EOSINOPHILS [J].

HOGGE, DE ;

MISAWA, S ;

PARSA, NZ ;

POLLAK, A ;

TESTA, JR .

JOURNAL OF CLINICAL ONCOLOGY, 1984, 2 (06) :550-557

[6] RAPID SUBCHROMOSOMAL LOCALIZATION OF COSMIDS BY NONRADIOACTIVE INSITU HYBRIDIZATION [J].

KIEVITS, T ;

DAUWERSE, JG ;

WIEGANT, J ;

DEVILEE, P ;

BREUNING, MH ;

CORNELISSE, CJ ;

VANOMMEN, GJB ;

PEARSON, PL .

CYTOGENETICS AND CELL GENETICS, 1990, 53 (2-3) :134-&

[7] FINE MAPPING OF THE HUNTINGTON DISEASE LINKED D4S10 LOCUS BY NONRADIOACTIVE INSITU HYBRIDIZATION [J].

LANDEGENT, JE ;

INDEWAL, NJ ;

FISSERGROEN, YM ;

BAKKER, E ;

VANDERPLOEG, M ;

PEARSON, PL .

HUMAN GENETICS, 1986, 73 (04) :354-357

[8] METALLOTHIONEIN GENE-CLUSTER IS SPLIT BY CHROMOSOME-16 REARRANGEMENTS IN MYELOMONOCYTIC LEUKEMIA [J].

LEBEAU, MM ;

DIAZ, MO ;

KARIN, M ;

ROWLEY, JD .

NATURE, 1985, 313 (6004) :709-711

[9] ASSOCIATION OF AN INVERSION OF CHROMOSOME-16 WITH ABNORMAL MARROW EOSINOPHILS IN ACUTE MYELOMONOCYTIC LEUKEMIA - A UNIQUE CYTOGENETIC CLINICOPATHOLOGICAL ASSOCIATION [J].

LEBEAU, MM ;

LARSON, RA ;

BITTER, MA ;

VARDIMAN, JW ;

GOLOMB, HM ;

ROWLEY, JD .

NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (11) :630-636

[10]

LIU P, 1989, CYTOGENET CELL GENET, V51, P1035

← 1 2 →