A CONVENIENT APPROACH TO THE SYNTHESIS OF MEDIUM SIZE DEOXYRIBOOLIGONUCLEOTIDES BY IMPROVED NEW PHOSPHITE METHOD

被引：7

作者：

HOSAKA, H ^{[1
]}

SUZUKI, Y ^{[1
]}

GUGKIM, S ^{[1
]}

TAKAKU, H ^{[1
]}

机构：

[1] CHIBA INST TECHNOL,DEPT IND CHEM,BIOORGAN CHEM LAB,NARASHINO,CHIBA 275,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)74886-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Improvement of the new phosphite method for the DNA synthesis using the deoxyribonucleoside 3'-bis(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite units (3) has been carried out via the hydrolysis and capping steps. A new capping agent, bis(1,1,1,3,3,3-hexafluoro-2-propyl)-2-propyl phosphite (HFPP) (6) is readily activated by N-methylimdazole under very mild conditions on a solid support.

引用

页码：785 / 788

页数：4

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