ACUTE ONSET DEAFNESS IN A 4-YEAR-OLD GIRL AFTER A SINGLE INFUSION OF CIS-PLATINUM

被引：19

作者：

BUHRER, C

WEINEL, P

SAUTER, S

REITER, A

RIEHM, H

LASZIG, R

机构：

[1] HANOVER MED SCH,DEPT PEDIAT,W-3000 HANOVER 61,GERMANY

[2] HANOVER MED SCH,DEPT EAR NOSE & THROAT,W-3000 HANOVER 61,GERMANY

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1990年 / 7卷 / 02期

关键词：

Cis-platinum; Hearing loss;

D O I：

10.3109/08880019009033384

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dose-dependent reduction of auditory Junction mainly in the high frequency range has been described as a common adverse side effect of cis-platinum. Here we report on a 4-year-old girl with osteosarcoma of the right distal femur who developed acute bilateral deafness 3 days after a single infusion of high-dose cis-platinum (150 mg/m2) during preoperative chemotherapy. Sudden disabling ototoxicity should be considered when administering high-dose cis-platinum to young children. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：145 / 148

页数：4

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