PEUTZ-JEGHERS SYNDROME ASSOCIATED WITH ADENOCARCINOMA OF THE CECUM AND FOCAL CARCINOMAS IN HAMARTOMATOUS POLYPS OF THE COLON - A CASE-REPORT

被引：13

作者：

NIIMI, K

TOMODA, H

FURUSAWA, M

HAYASHI, I

OKUMURA, Y

机构：

[1] The Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, 815, 3-1-1, Notame, Minami-ku

[2] Department of Pathology, National Kyushu Cancer Cancer, Fukuoka, 815, 3-1-1, Notame, Minami-ku

[3] Department of Radiology, Natioanl Kyushu Cancer Center, Fukuoka, 815, 3-1-1, Notame, Minami-ku

来源：

JAPANESE JOURNAL OF SURGERY | 1991年 / 21卷 / 02期

关键词：

PEUTZ-JEGHERS SYNDROME; HAMARTOMA; COLONIC MALIGNANCIES;

D O I：

10.1007/BF02470912

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

We report herein a case of Peutz-Jeghers syndrome associated with an adenocarcinoma of the cecum and four focal cancers arising in hamartomatous polyps of the colon. There were a total 27 polyps in the intestine; 4 in the small intestine and the rest in the large intestine. The hamartomatous polyps in which the 4 focal cancers were found showed no component of adenoma, and the other polyps removed from the colon and small intestine at the same time were all hamartomas with no evidence of dysplasia or malignancy. This case was rare in that multiple focal cancers may have arisen directly from the hamartomous polyps of the colon.

引用

页码：220 / 223

页数：4

共 19 条

[1]

Peutz J.L.A., On a very remarkable case of familial polyposis of the mucous membrane of the intestinal tract and nasopharynx accompanied by peculiar pigmentations of the skin and mucous membrane, Ned Tijdosch Geneeskd, 10, pp. 134-146, (1921)

[2]

Jeghers H., McKusick V.A., Katz K.H., Generalized intestinal polyposis and melanin spots of the oral mucosa, lip and digitis: a syndrome of diagnostic significance, N Engl J Med, 241, pp. 1031-1036, (1949)

[3]

Mishima Y., Yaegashi K., Japanese registry for adenomatosis coli, J Jpn Soc Colo-proct, 40, pp. 689-698, (1987)

[4]

Bartholomew L.G., Dahlin D.C., Waugh J.M., Intestinal polyposis associated with mucocutaneous melanin pigmentation (Peutz-Jeghers syndrome)

[5]

Review of literature and report of six cases with special reference to pathological findings, Gastroenterol, 32, pp. 434-451, (1957)

[6]

Cochet B., Carrel J., Desbaillets L., Widgren S., Petz-Jeghers sydrome associated with gastrointestinal carcinoma: Report of two cases in a family, Gut, 20, pp. 169-175, (1979)

[7]

Humphries A.L., Shepherd M.H., Peters H.J., Peutz-Jeghers syndrome with colonic adenocarcinoma and ovarian tumor, JAMA: The Journal of the American Medical Association, 197, pp. 296-298, (1966)

[8]

Giardiello F.M., Welsh S.B., Hamilton S.R., Offerhaus J.A., Gittelsohn A.M., Booker S.V., Krush A.J., Yardley J.H., Luk G.D., Increased risk of cancer in the Peutz-Jeghers syndrome, N Engl J Med, 316, pp. 1511-1514, (1987)

[9]

Reid J.D., Intestinal carcinoma in the Peutz-Jeghers syndrome, J Am Med Assoc, 229, pp. 833-834, (1974)

[10]

Berkowitz S.B., Pearl M.L., Shapiro N.H., Syndrome of intestinal polyposis with melanosis of the lips and buccal mucosa

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