1,1'-ETHYLIDENEBIS(L-TRYPTOPHAN), STRUCTURE DETERMINATION OF CONTAMINANT-97 - IMPLICATED IN THE EOSINOPHILIA-MYALGIA-SYNDROME (EMS)

被引：56

作者：

SMITH, MJ

MAZZOLA, EP

FARRELL, TJ

SPHON, JA

PAGE, SW

ASHLEY, D

SIRIMANNE, SR

HILL, RH

NEEDHAM, LL

机构：

[1] US FDA, CTR FOOD SAFETY & APPL NUTR, FOOD FORMULAT BRANCH, WASHINGTON, DC 20204 USA

[2] CTR DIS CONTROL, CTR ENVIRONM HLTH & INJURY CONTROL, TOXICOL BRANCH, ATLANTA, GA 30333 USA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)74469-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The condensation of tryptophan and acetaldehyde affords a bisindolylaminal of tryptophan which is indistinguishable from contaminant "97". The formation and decomposition of aminals is addressed in light of epidemiological evidence linking them to a recent outbreak of EMS.

引用

页码：991 / 994

页数：4

共 19 条

[1] AN INVESTIGATION OF THE CAUSE OF THE EOSINOPHILIA-MYALGIA SYNDROME ASSOCIATED WITH TRYPTOPHAN USE [J].