3-0-ALKYLASCORBIC ACIDS AS FREE-RADICAL QUENCHERS .3. PROTECTIVE EFFECT ON CORONARY-OCCLUSION REPERFUSION INDUCED ARRHYTHMIAS IN ANESTHETIZED RATS

被引：31

作者：

NIHRO, Y ^{[1
]}

SOGAWA, S ^{[1
]}

IZUMI, A ^{[1
]}

SASAMORI, A ^{[1
]}

SUDO, T ^{[1
]}

MIKI, T ^{[1
]}

MATSUMOTO, H ^{[1
]}

SATOH, T ^{[1
]}

机构：

[1] NIPPON HYPOX LAB INC, DRUG CREATING LABS, MINAMIKOMA, YAMANASHI 40922, JAPAN

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 35卷 / 09期

关键词：

D O I：

10.1021/jm00087a017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury. These ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats. We found that 3-O-[(dodecylcarbonyl)methyl]ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-O-Octadecylascorbic acid (19) and 5,6-O-dodecylideneascorbic acid (15) also exhibited a marked effect on reperfusion injury, but significantly reduced the arterial blood pressure and heart rate in rats.

引用

页码：1618 / 1623

页数：6

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