VOLTAMMETRY OF EXTRACELLULAR DOPAMINE IN RAT STRIATUM DURING ICSS-LIKE ELECTRICAL-STIMULATION OF THE MEDIAL FOREBRAIN-BUNDLE

被引：25

作者：

YOUNG, SD ^{[1
]}

MICHAEL, AC ^{[1
]}

机构：

[1] UNIV PITTSBURGH,CHEVRON SCI CTR,DEPT CHEM,PITTSBURGH,PA 15260

来源：

BRAIN RESEARCH | 1993年 / 600卷 / 02期

关键词：

INVIVO VOLTAMMETRY; FAST-SCAN CYCLIC VOLTAMMETRY; DOPAMINE; ELECTRICAL STIMULATION; INTRACRANIAL SELF-STIMULATION; UPTAKE INHIBITION; NOMIFENSINE;

D O I：

10.1016/0006-8993(93)91387-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fast-scan cyclic voltammetry in the striatum of anesthetized rats has been used to monitor extracellular dopamine during forced electrical stimulation of the media forebrain bundle using parameters that mimic intracranial self-stimulation. The temporal resolution provided by microelectrodes positioned very near sites of dopamine release allows resolution of the response to individual 500-ms stimulation trains separated by 500-ms intervals. Uptake inhibition by Nomifensine alters the resolution obtained at short times after initiation of stimulation.

引用

页码：305 / 307

页数：3

共 20 条

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