ISONIAZID-ASSOCIATED RHABDOMYOLYSIS

被引：12

作者：

BLOWEY, DL

JOHNSON, D

VERJEE, Z

机构：

[1] Division of Clinical Pharmacology, The Hospital for Sick Children, University of Toronto, Ont.

[2] the Division of Toxicology, The Hospital for Sick Children, University of Toronto, Ont.

[3] Emergency Services, The Hospital for Sick Children, University of Toronto, Ont.

[4] Clinical Biochemistry, The Hospital for Sick Children, University of Toronto, Ont.

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 1995年 / 13卷 / 05期

关键词：

ISONIAZID; RHABDOMYOLYSIS; HEPATITIS;

D O I：

10.1016/0735-6757(95)90168-X

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We report the occurrence of rhabdomyolysis and hepatitis in a 17-year-old girl after the ingestion of up to 10.8 g of isoniazid. The initial isoniazid concentration in the blood was 1,230 mmol/L. There were no findings indicating the ingestion of other substances known to be associated with rhabdomyolysis. In addition to rhabdomyolysis (peak creatine phosphokinase 88,000 U/L), the patient had a significant elevation of her liver enzymes (peak aspartate aminotransferase 1,980 U/L). She recovered completely without evidence of liver or renal damage. Rhabdomyolysis and isoniazid induced hepatitis are complications that should be considered when Earing for patients with acute isoniazid ingestion. (C) 1995 by W.B. Saunders Company

引用

页码：543 / 544

页数：2

共 10 条

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[10] Mitchell, Zimmerman, Ishak, Et al., Isoniazid liver injury: Clinical spectrum, pathology and probable pathogenesis, Ann Intern Med, 84, pp. 181-192, (1976)

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