ELEVATION OF CARBAMAZEPINE PLASMA-LEVELS BY DILTIAZEM IN RABBITS - A POTENTIALLY IMPORTANT DRUG-INTERACTION

被引：3

作者：

ALHUMAYYD, MS

机构：

[1] Department of Medical Pharmacology, College of Medicine, King Saud University, Riyadh, 11461

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1990年 / 11卷 / 05期

关键词：

Carbamazepine; Diltiazem; Interaction; Rabbits;

D O I：

10.1002/bdd.2510110506

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of diltiazem on the plasma level of carbamazepine (CBZ) was investigated in rabbits. The animals were given either CBZ alone or in combination with diltiazem and plasma samples were collected at different time intervals. The concentration of CBZ was detected using an HPLC method. Diltiazem significantly increased the area under the curve (AUC), the maximum plasma concentration (Cmax), and the elimination half‐life (t1/2) of CBZ (p < 0·05). These results suggest that a potentially harmful drug‐ drug interaction may occur if CBZ and diltiazem are administered concurrently. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：411 / 417

页数：7

共 22 条

[1] CARBAMAZEPINE NEUROTOXICITY PRECIPITATED BY DILTIAZEM [J].