FETAL AND MATERNAL LEVELS OF CORTICOSTERONE AND ACTH AFTER PHARMACOLOGICAL ADRENALECTOMY

被引：25

作者：

BARAM, TZ

SCHULTZ, L

机构：

[1] Dept. Neurology, University of Southern California

来源：

LIFE SCIENCES | 1990年 / 47卷 / 06期

关键词：

D O I：

10.1016/0024-3205(90)90607-S

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A paradigm of pharmacological adrenalectomy of pregnant rats and fetuses in utero is described. A regimen of twice daily metyrapone injections (10mg/100gm body weight), results in marked depression of serum corticosterone in pregnant and in fetal rats without surgical trauma and stress. The technique should be useful in a wide variety of studies involving the developing brain-adrenal axis. © 1990.

引用

页码：485 / 489

页数：5

共 8 条

[1] MATERNAL-FETAL INTERRELATIONS OF PLASMA CORTICOSTERONE CONCENTRATIONS AT END OF GESTATION IN RAT
ARISHIMA, K
NAKAMA, S
MORIKAWA, Y
HASHIMOTO, Y
EGUCHI, Y
[J]. JOURNAL OF ENDOCRINOLOGY, 1977, 72 (02) : 239 - 240
[2] BARAM TZ, IN PRESS NEUROSCI LE
[3] CHATELAIN A, 1980, ENDOCRINOLOGY, V106, P1297
[4] INVITRO EFFECTS OF CORTICOSTERONE, SYNTHETIC OVINE CORTICOTROPIN RELEASING-FACTOR AND ARGININE VASOPRESSIN ON THE RELEASE OF ADRENOCORTICOTROPIN BY FETAL-RAT PITUITARY-GLANDS
DUPOUY, JP
CHATELAIN, A
[J]. JOURNAL OF ENDOCRINOLOGY, 1984, 101 (03) : 339 - 344
[5] ONTOGENY OF EXPRESSION OF THE CORTICOTROPIN-RELEASING FACTOR GENE IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS AND OF THE PROOPIOMELANOCORTIN GENE IN RAT PITUITARY
GRINO, M
YOUNG, WS
BURGUNDER, JM
[J]. ENDOCRINOLOGY, 1989, 124 (01) : 60 - 68
[6] Jost A, 1966, Recent Prog Horm Res, V22, P541
[7] HYPOPHYSEAL-PORTAL PLASMA-LEVELS, MEDIAN-EMINENCE CONTENT, AND IMMUNOHISTOCHEMICAL STAINING OF CORTICOTROPIN-RELEASING FACTOR, ARGININE VASOPRESSIN, AND OXYTOCIN AFTER PHARMACOLOGICAL ADRENALECTOMY
PLOTSKY, PM
SAWCHENKO, PE
[J]. ENDOCRINOLOGY, 1987, 120 (04) : 1361 - 1369
[8] MATURATION OF THE ADRENOCORTICAL STRESS RESPONSE - NEUROENDOCRINE CONTROL MECHANISMS AND THE STRESS HYPORESPONSIVE PERIOD
SAPOLSKY, RM
MEANEY, MJ
[J]. BRAIN RESEARCH REVIEWS, 1986, 11 (01) : 65 - 76

← 1 →