IL-2-DEPENDENT GENERATION OF NATURAL-KILLER-CELLS FROM BONE-MARROW - ROLE OF MAC-1-, NK1-1- PRECURSORS

被引：12

作者：

MIGLIORATI, G

MORACA, R

NICOLETTI, I

RICCARDI, C

机构：

[1] UNIV PERUGIA, SCH MED, INST PHARMACOL, VIA GIOCHETTO, I-06100 PERUGIA, ITALY

[2] UNIV PERUGIA, SCH MED, INST INTERNAL MED, I-06100 PERUGIA, ITALY

来源：

CELLULAR IMMUNOLOGY | 1992年 / 141卷 / 02期

关键词：

D O I：

10.1016/0008-8749(92)90151-E

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have previously shown that interleukin-2 (IL-2) is able to induce the generation of natural killer (NK) activity in bone marrow (BM) cell cultures from mice pretreated with 5-fluorouracil (5-FU). Cell fractionation experiments to analyze the nature of BM precursors indicate that MAC-1-, NK1-1- noncytotoxic precursors are induced by IL-2 to proliferate and generate cytolytic NK cells. These data demonstrate that the phenotype and functional characteristics of the IL-2-responsive cells in the FUBM are different from those of mature NK cells in that they are MAC-1+, NK1.1+, CD3- and susceptible to boosting by IFN-α. © 1992.

引用

页码：323 / 331

页数：9

共 32 条

[1] PROGRESSIVE LOSS OF H-2 ANTIGENS WITH CONCOMITANT INCREASE OF CELL-SURFACE ANTIGEN(S) DETERMINED BY MOLONEY LEUKEMIA-VIRUS IN CULTURED MURINE LYMPHOMAS [J].