GENERAL FEATURES OF THE HEPARIN-BINDING SERPINS ANTITHROMBIN, HEPARIN COFACTOR-II AND PROTEIN-C INHIBITOR

被引:57
作者
PRATT, CW
CHURCH, FC
机构
[1] UNIV N CAROLINA,SCH MED,CTR THROMBOSIS & HEMOSTASIS,DEPT PATHOL,DIV HEMATOL,CAMPUS BOX 7035,CHAPEL HILL,NC 27599
[2] UNIV N CAROLINA,SCH MED,CTR THROMBOSIS & HEMOSTASIS,DEPT MED,CHAPEL HILL,NC 27599
关键词
SERPINS; HEPARIN; GLYCOSAMINOGLYCAN; ANTITHROMBIN; THROMBIN; ACTIVATED PROTEIN-C; REVIEW;
D O I
10.1097/00001721-199306000-00013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The blood plasma serine proteinase inhibitors (serpins) are glycoproteins whose activities are involved in many important homeostatic reactions. The heparin-dependent plasma serpins, antithrombin, heparin cofactor II and protein C inhibitor, regulate the proteinases of blood coagulation. Heparin and some other glycosaminoglycans increase the rate of proteinase inhibition by these three plasma serpins. Proteinases recognize a specific peptide, termed the reactive site, near the carboxyl-terminus of serpins (for antithrombin and protein C inhibitor this is Arg-Ser and for heparin cofactor II this is Leu-Ser). Additionally, these three serpins contain unique structural elements that confer glycosaminoglycan binding activities. The therapeutic anticoagulant action of the glycosaminoglycan heparin is believed to depend partially on heparin-accelerated inhibition of proteinases by antithrombin. The physiological importance of specific proteoglycans has been attributed to their recognition of these serpins and their biological 'activation' of these proteinase inhibitors.
引用
收藏
页码:479 / 490
页数:12
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