REACTION OF SOME DIKETONES WITH 5-AMINOLEVULINIC ACID IN ACID-SOLUTION

被引:14
作者
BUTLER, AR
GEORGE, SD
机构
[1] Chemistry Department, University of St Andrews Fife
关键词
D O I
10.1016/S0040-4020(01)87976-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Some 2,4-diketones react with 5-aminolevulinic acid in acid solution to form pyrroles. There are two modes of cyclisation, one leading to the Knorr and the other to the Fischer-Fink product. By a consideration of the products obtained from pentane-, hexane-, 3-methylpentane-, 3-isopropylpentane-, 3,3-dimethylpentane-, 1,1,1-trifluoropentane-1,1,1,5,5,5-hexafluoro- pentane-2,4-dione and ethyl acetoacetate some generalisations concerning the formation of Knorr and Fischer-Fink products have been made. The reactions of 5-methyl-5-aminolevulinic acid with pentane- and 3-methylpentane-2,4-dione have also been examined, The relevance of these studies to the cyclic dimerisation of 5-aminolevulinic acid is discussed briefly.
引用
收藏
页码:7017 / 7026
页数:10
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