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THE BTB DOMAIN, FOUND PRIMARILY IN ZINC-FINGER PROTEINS, DEFINES AN EVOLUTIONARILY CONSERVED FAMILY THAT INCLUDES SEVERAL DEVELOPMENTALLY-REGULATED GENES IN DROSOPHILA

被引：394
作者：
ZOLLMAN, S
GODT, D
PRIVE, GG
COUDERC, JL
LASKI, FA
机构：
[1] UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024
[3] UNIV CALIF LOS ANGELES,HOWARD HUGHES MED INST,LOS ANGELES,CA 90024
[4] INSERM,U384,UNITE FORMAT & RECH MED,BIOCHEM LAB,F-63001 CLERMONT FERRAND,FRANCE
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 22期
关键词：
BRIC A BRAC; TRAMTRACK; TRANSCRIPTIONAL REGULATION; AMINO TERMINAL DOMAIN; EMBRYOGENESIS;
D O I：
10.1073/pnas.91.22.10717
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Drosophila bric a brac protein and the transcriptional regulators encoded by tramtrack and Broad-Complex contain a highly conserved domain of approximate to 115 amino acids, which we have called the BTB domain. We have identified six additional Drosophila genes that encode this domain. Five of these genes are developmentally regulated, and one of them appears to be functionally related to bric a brac. The BTB domain defines a gene family with an estimated 40 members in Drosophila. This domain is found primarily at the N terminus of zinc finger proteins and is evolutionarily conserved from Drosophila to mammals.
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页码：10717 / 10721
页数：5
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