INDUCTION OF NITROTYROSINE-LIKE IMMUNOREACTIVITY IN THE LOWER MOTOR-NEURON OF AMYOTROPHIC-LATERAL-SCLEROSIS

被引：222

作者：

ABE, K

PAN, LH

WATANABE, M

KATO, T

ITOYAMA, Y

机构：

[1] TOHOKU UNIV, SCH MED, DEPT PATHOL, AOBA KU, SENDAI, MIYAGI 980, JAPAN

[2] GUNMA UNIV, SCH MED, DEPT NEUROL, MAEBASHI, GUMMA 371, JAPAN

[3] YAMAGATA UNIV, SCH MED, DEPT INTERNAL MED 3, YAMAGATA 99023, JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 199卷 / 02期

关键词：

NITROTYROSINE; SUPEROXIDE DISMUTASE; AMYOTROPHIC LATERAL SCLEROSIS;

D O I：

10.1016/0304-3940(95)12039-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinal cords of sporadic cases with amyotrophic lateral sclerosis (ALS) and normal controls were immunohistochemically examined using antibodies for Cu/Zn superoxide dismutase (SOD) and nitrotyrosine (NT). Immunoreactivity for Cu/Zn SOD of the motor neurons was not different between the ALS and controls, In contrast, immunoreactivity for NT was densely detected in motor neurons of ALS but was not or was only minimally detected in those of controls. The staining was also found in the axons of motor neurons of ALS, but was not found in the controls. These results suggest that nitration of protein-tyrosine residue is upregulated in motor neurons of the spinal cord of ALS.

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页码：152 / 154

页数：3

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