THE 70-KDA S6-KINASE - REGULATION OF A KINASE WITH MULTIPLE ROLES IN MITOGENIC SIGNALING

被引：240

作者：

CHOU, MM

BLENIS, J

机构：

[1] Harvard Medical School, Boston

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 06期

关键词：

D O I：

10.1016/0955-0674(95)80064-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The activation of the 70kDa S6 kinase, pp70(S6k), is a well documented mitogenic response, yet until recently little was known of how pp70(S6k) is activated, or of the identities of its crucial targets. The past year has revealed the complexity of pp70(S6k) regulation, with the overriding theme being that enzymes which have proven or putative roles in phospholipid metabolism mediate its activation. Studies also indicate that pp70(S6k) may regulate many more pathways than previously recognized.

引用

页码：806 / 814

页数：9

共 72 条

[1] INHIBITION OF HUMAN B-LYMPHOCYTE CELL-CYCLE PROGRESSION AND DIFFERENTIATION BY RAPAMYCIN
AAGAARDTILLERY, KM
JELINEK, DF
[J]. CELLULAR IMMUNOLOGY, 1994, 156 (02) : 493 - 507
[2] ALBERS MW, 1993, J BIOL CHEM, V268, P22825
[3] WORTMANNIN IS A POTENT PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR - THE ROLE OF PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE IN NEUTROPHIL RESPONSES
ARCARO, A
WYMANN, MP
[J]. BIOCHEMICAL JOURNAL, 1993, 296 : 297 - 301
[4] MOLECULAR-STRUCTURE OF A MAJOR INSULIN MITOGEN-ACTIVATED 70-KDA S6 PROTEIN-KINASE
BANERJEE, P
AHMAD, MF
GROVE, JR
KOZLOSKY, C
PRICE, DJ
AVRUCH, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (21) : 8550 - 8554
[5] BAUERLE PA, 1994, ANNU REV IMMUNOL, V12, P141
[6] BLENIS J, 1991, CELL GROWTH DIFFER, V2, P279
[7] A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX
BROWN, EJ
ALBERS, MW
SHIN, TB
ICHIKAWA, K
KEITH, CT
LANE, WS
SCHREIBER, SL
[J]. NATURE, 1994, 369 (6483) : 756 - 758
[8] CONTROL OF P70 S6 KINASE BY KINASE-ACTIVITY OF FRAP IN-VIVO
BROWN, EJ
BEAL, PA
KEITH, CT
CHEN, J
SHIN, TB
SCHREIBER, SL
[J]. NATURE, 1995, 377 (6548) : 441 - 446
[9] DOMINANT MISSENSE MUTATIONS IN A NOVEL YEAST PROTEIN RELATED TO MAMMALIAN PHOSPHATIDYLINOSITOL 3-KINASE AND VPS34 ABROGATE RAPAMYCIN CYTOTOXICITY
CAFFERKEY, R
YOUNG, PR
MCLAUGHLIN, MM
BERGSMA, DJ
KOLTIN, Y
SATHE, GM
FAUCETTE, L
ENG, WK
JOHNSON, RK
LIVI, GP
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (10) : 6012 - 6023
[10] INTERLEUKIN-2 STIMULATION OF P70 S6 KINASE-ACTIVITY IS INHIBITED BY THE IMMUNOSUPPRESSANT RAPAMYCIN
CALVO, V
CREWS, CM
VIK, TA
BIERER, BE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) : 7571 - 7575

← 1 2 3 4 5 6 7 8 →