INHIBITION OF LIPOLYTIC RESPONSE TO NERVE-STIMULATION DURING ACIDOSIS

Acidosis inhibits catecholamine-induced lipolysis in vivo and in vitro. The lipolytic response of canine subcutaneous adipose tissue to short (5 min) nerve stimulations at 4 Hz was not influenced by hypercapnic acidosis (pH 7.0). The steady state outflow of glycerol during vasodilatation induced by a 4 Hz stimulation in .alpha.-blocked adipose tissue was inhibited by 37% (P < 0.05). Post-stimulatory glycerol outflow was not influenced by acidosis. This poststimulatory glycerol outflow, which may represent a complex wash-out phenomenon, forms the largest part of the response to short nerve stimulations. Steady state, rather than poststimulatory lipolysis should probably be studied in order to see the influence of treatments such as acidosis on responses to nerve stimulation.