SYNTHESIS OF GAMMA-LACTAM ANALOGS OF 1-ACETOXY CARBAPENEM DERIVATIVES

被引：11

作者：

COULTON, S

FRANCOIS, I

SOUTHGATE, R

机构：

[1] SmithKline Beecham Pharmaceuticals, Research Division, Betchworth, Surrey RH3 7AJ, Brockham Park

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)97208-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of γ-lactam analogues of the 1-acetoxy carbapenem esters, from dl-pyroglutamic acid are described. Attempted deprotection to provide the free carboxylic acids resulted in degradation. Whilst the free acid of the 1-hydroxy carbapenem analogue was chemically stable, it lacked antibacterial activity. © 1990.

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页码：6923 / 6926

页数：4

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