ZINC(II)-CHLORIDE INDUCED THIOALKYLATION OF ALUMINUM ENOLATES - ENANTIOSELECTIVE SYNTHESIS OF ESTRADIOL-3-METHYL-17-TERT-BUTYL DIETHER

被引：21

作者：

GROTH, U

KOHLER, T

TAAPKEN, T

机构：

[1] Institut für Organische Chemie der Universität Göttingen, D-3400 Göttingen

来源：

TETRAHEDRON | 1991年 / 47卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(01)88282-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Zinc(II)-chloride induced thioalkylation of the aluminium enolate 6 generated by conjugate reduction of the enone 5 leads - directly or via its trimethylsilylenol ether 6 - to alkylated hydrindanones 10 which are important intermediates in the synthesis of 19-norsteroids such as the title compound estradiol-3-methyl-17-tert-butyl diether 12.

引用

页码：7583 / 7592

页数：10

共 22 条

[1] NOVEL TOTAL SYNTHESES OF (+)-ESTRONE 3-METHYL ETHER, (+)-13BETA-ETHYL-3-METHOXYGONA-1,3,5(10)-TRIEN-17-ONE, AND (+)-EQUILENIN 3-METHYL ETHER [J].