NEW HYDRAZONE DERIVATIVES OF ADRIAMYCIN AND THEIR IMMUNOCONJUGATES - A CORRELATION BETWEEN ACID STABILITY AND CYTOTOXICITY

被引：144

作者：

KANEKO, T ^{[1
]}

WILLNER, D ^{[1
]}

MONKOVIC, I ^{[1
]}

KNIPE, JO ^{[1
]}

BRASLAWSKY, GR ^{[1
]}

GREENFIELD, RS ^{[1
]}

VYAS, DM ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB CO,5 RES PKWY,POB 5100,WALLINGFORD,CT 06492

来源：

BIOCONJUGATE CHEMISTRY | 1991年 / 2卷 / 03期

关键词：

D O I：

10.1021/bc00009a001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

New N-substituted hydrazine linkers were synthesized and their hydrazone derivatives of adriamycin were prepared. These functionalized adriamycin derivatives were conjugated with a monoclonal antibody, 5E9. The release rate of adriamycin from the hydrazones and from some of the conjugates was studied, and their relationship to the IC50's of the conjugate against 5E9-positive Daudi cells was investigated.

引用

页码：133 / 141

页数：9

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