EFFECT OF PASSAGING ON MER PHENOTYPE OF HUMAN FETAL CELL-CULTURES

被引：7

作者：

DAY, RS ^{[1
]}

HONORE, LH ^{[1
]}

DOBLER, KD ^{[1
]}

机构：

[1] UNIV ALBERTA, WALTER C MACKENZIE HLTH SCI CTR, FAC MED, DEPT PATHOL, EDMONTON T6G 2B7, ALBERTA, CANADA

来源：

MUTATION RESEARCH | 1991年 / 254卷 / 02期

关键词：

PASSAGING; EFFECT ON MER PHENOTYPE; MER+ PHENOTYPE; HUMAN FETAL CELL CULTURES;

D O I：

10.1016/0921-8777(91)90006-B

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

With increasing passage in culture, the human fibroblast cell strain GM11 lost the Mer+ phenotype (the ability to support the growth of adenovirus 5 damaged prior to infection by MNNG). All of 46 embryonic strains prepared either from various organs of 20 fetuses from 6-7 to 13-14 weeks of gestational age or from two hydatidiform moles showed normal repair of MNNG-treated virus. We conclude that human fetal strains are not usually deficient in such repair, and that the behavior of GM11 is atypical.

引用

收藏

页码：153 / 160

页数：8

相关论文

共 25 条

[1]

BAKER RM, 1980, ENVIRON MUTAGEN, V2, P269

[2] HELA-CELL VARIANTS THAT DIFFER IN SENSITIVITY TO MONOFUNCTIONAL ALKYLATING-AGENTS, WITH INDEPENDENCE OF CYTOTOXIC AND MUTAGENIC RESPONSES [J].

BAKER, RM ;

VANVOORHIS, WC ;

SPENCER, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (10) :5249-5253

[3] REPAIR OF O-6-METHYLGUANINE IN HUMAN-FETAL BRAIN AND SKIN CELLS IN CULTURE [J].

DAMBROSIO, SM ;

WANI, G ;

SAMUEL, M ;

GIBSONDAMBROSIO, RE .

CARCINOGENESIS, 1984, 5 (12) :1657-1661

[4] HUMAN-TUMOR CELL STRAINS DEFECTIVE IN THE REPAIR OF ALKYLATION DAMAGE [J].

DAY, RS ;

ZIOLKOWSKI, CHJ ;

SCUDIERO, DA ;

MEYER, SA ;

MATTERN, MR .

CARCINOGENESIS, 1980, 1 (01) :21-32

[5] HUMAN-BRAIN TUMOR-CELL STRAINS WITH DEFICIENT HOST-CELL REACTIVATION OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE-DAMAGED ADENOVIRUS-5 [J].

DAY, RS ;

ZIOLKOWSKI, CHJ .

NATURE, 1979, 279 (5716) :797-799

[6] DEFECTIVE REPAIR OF ALKYLATED DNA BY HUMAN-TUMOR AND SV40-TRANSFORMED HUMAN CELL STRAINS [J].

DAY, RS ;

ZIOLKOWSKI, CHJ ;

SCUDIERO, DA ;

MEYER, SA ;

LUBINIECKI, AS ;

GIRARDI, AJ ;

GALLOWAY, SM ;

BYNUM, GD .

NATURE, 1980, 288 (5792) :724-727

[7]

DAY RS, 1987, J CELL SCI, P333

[8] CORRELATION BETWEEN O-6-METHYLGUANINE-DNA-METHYLTRANSFERASE ACTIVITY AND RESISTANCE OF HUMAN-CELLS TO THE CYTO-TOXIC AND MUTAGENIC EFFECT OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE [J].

DOMORADZKI, J ;

PEGG, AE ;

DOLAN, ME ;

MAHER, VM ;

MCCORMICK, JJ .

CARCINOGENESIS, 1984, 5 (12) :1641-1647

[9] QUANTITATIVE ASSESSMENT OF THE ROLE OF O-6-METHYLGUANINE IN THE INITIATION OF CARCINOGENESIS BY METHYLATING AGENTS [J].

DONIGER, J ;

DAY, RS ;

DIPAOLO, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (02) :421-425

[10] COMPLETE AND PARTIAL HYDATIDIFORM MOLE IN HAWAII - CYTOGENETICS, MORPHOLOGY AND EPIDEMIOLOGY [J].

JACOBS, PA ;

HUNT, PA ;

MATSUURA, JS ;

WILSON, CC ;

SZULMAN, AE .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1982, 89 (04) :258-266