TYRAMINE ANTAGONIZES PROCTOLIN-INDUCED CONTRACTION OF THE ISOLATED FOREGUT OF THE LOCUST SCHISTOCERCA-GREGARIA BY AN INTERACTION WITH OCTOPAMINE-2 RECEPTORS

被引：11

作者：

BANNER, SE ^{[1
]}

WOOD, SJ ^{[1
]}

OSBORNE, RH ^{[1
]}

CATTELL, KJ ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT, MED RES CTR, HARLOW, ESSEX, ENGLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1990年 / 95卷 / 02期

关键词：

D O I：

10.1016/0742-8413(90)90110-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Octopamine (OA) (10-7-10-5M) relaxed isolated foreguts. Tyramine mimicked the effects of OA but was 64 × less potent. 2. 2. Proctolin (10-8 M to 10-6M) induced contraction of isolated foreguts was antagonised non competitively by tyramine. 3. 3. Mianserin (10-6 M) was a non competitive antagonist of relaxation caused by tyramine but was without effect on proctolin induced contraction. 4. 4. Caffeine (1 μM and 2 μM) caused non competitive inhibition of proctolin-induced tissue contraction. 5. 5. It is concluded that tyramine antagonises proctolin-induced contraction of the foregut by activating an adenylate cyclase-linked OA2 receptor. © 1990.

引用

页码：233 / 236

页数：4

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