DIFFERENT PATHWAYS OF ENDOTHELIN SARAFOTOXIN-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN MYOCYTES

被引：16

作者：

GALRON, R

KLOOG, Y

BDOLAH, A

SOKOLOVSKY, M

机构：

[1] TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM,NEUROBIOCHEM LAB,IL-69978 TEL AVIV,ISRAEL

[2] TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT ZOOL,IL-69978 TEL AVIV,ISRAEL

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1990年 / 188卷 / 01期

关键词：

HEART (RAT); PHOSPHOINOSITIDE HYDROLYSIS; ENDOTHELINS; SARAFOTOXINS; AGING; (RECEPTOR);

D O I：

10.1016/0922-4106(90)90251-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aging of rat heart myocytes in culture is accompanied by approximately 50% reduction in endothelin (ET)/sarafotoxin (SRTX) receptor-binding capacity as well as in the induction of phosphoinositide (PI) hydrolysis. Treatment of aged cultures under conditions yielding myocytes with a lipid composition similar to that in young cultures restored all the ET/SRTX receptors; at the same time it re-established only the endothelin-induced but not the sarafotoxin-induced PI-hydrolysis response. Thus more than one mechanism may stimulate PI metabolism.

引用

页码：85 / 88

页数：4

共 9 条

[1] CHARACTERIZATION AND LOCALIZATION OF A NOVEL NEURORECEPTOR FOR THE PEPTIDE SARAFOTOXIN
AMBAR, I
KLOOG, Y
KOCHVA, E
WOLLBERG, Z
BDOLAH, A
ORON, U
SOKOLOVSKY, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (03) : 1104 - 1110
[2] COMPETITIVE INTERACTION BETWEEN ENDOTHELIN AND SARAFOTOXIN - BINDING AND PHOSPHOINOSITIDES HYDROLYSIS IN RAT ATRIA AND BRAIN
AMBAR, I
KLOOG, Y
SCHVARTZ, I
HAZUM, E
SOKOLOVSKY, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (01) : 195 - 201
[3] FUNCTIONAL ENDOTHELIN SARAFOTOXIN RECEPTORS IN RAT-HEART MYOCYTES - STRUCTURE-ACTIVITY-RELATIONSHIPS AND RECEPTOR SUBTYPES
GALRON, R
KLOOG, Y
BDOLAH, A
SOKOLOVSKY, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (02) : 936 - 943
[4] SARAFOTOXIN RECEPTORS MEDIATE PHOSPHOINOSITIDE HYDROLYSIS IN VARIOUS RAT-BRAIN REGIONS
KLOOG, Y
AMBAR, I
KOCHVA, E
WOLLBERG, Z
BDOLAH, A
SOKOLOVSKY, M
[J]. FEBS LETTERS, 1989, 242 (02) : 387 - 390
[5] SIMILARITIES IN MODE AND SITES OF ACTION OF SARAFOTOXINS AND ENDOTHELINS
KLOOG, Y
SOKOLOVSKY, M
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (06) : 212 - 214
[6] GUANOSINE 5'-TRIPHOSPHATE BINDING-PROTEIN (GI) AND 2 ADDITIONAL PERTUSSIS TOXIN SUBSTRATES ASSOCIATED WITH MUSCARINIC RECEPTORS IN RAT-HEART MYOCYTES - CHARACTERIZATION AND AGE DEPENDENCY
MOSCONAAMIR, E
HENIS, YI
SOKOLOVSKY, M
[J]. BIOCHEMISTRY, 1988, 27 (14) : 4985 - 4991
[7] AGING OF RAT-HEART MYOCYTES DISRUPTS MUSCARINIC RECEPTOR COUPLING THAT LEADS TO INHIBITION OF CAMP ACCUMULATION AND ALTERS THE PATHWAY OF MUSCARINIC-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS
MOSCONAAMIR, E
HENIS, YI
SOKOLOVSKY, M
[J]. BIOCHEMISTRY, 1989, 28 (17) : 7130 - 7137
[8] MOSCONAAMIR E, 1986, BIOCHEMISTRY-US, V25, P1118
[9] SARAFOTOXINS-S6 - SEVERAL ISOTOXINS FROM ATRACTASPIS-ENGADDENSIS (BURROWING ASP) VENOM THAT AFFECT THE HEART
TAKASAKI, C
TAMIYA, N
BDOLAH, A
WOLLBERG, Z
KOCHVA, E
[J]. TOXICON, 1988, 26 (06) : 543 - 548

← 1 →