TREATMENT OF ADVANCED AND RECURRENT ENDOMETRIAL CANCER WITH CISPLATIN, DOXORUBICIN, AND CYCLOPHOSPHAMIDE

被引：37

作者：

DUNTON, CJ ^{[1
]}

PFEIFER, SM ^{[1
]}

BRAITMAN, LE ^{[1
]}

MORGAN, MA ^{[1
]}

CARLSON, JA ^{[1
]}

MIKUTA, JJ ^{[1
]}

机构：

[1] HOSP UNIV PENN,CTR CANC,BIOSTAT UNIT,PHILADELPHIA,PA 19104

来源：

GYNECOLOGIC ONCOLOGY | 1991年 / 41卷 / 02期

关键词：

D O I：

10.1016/0090-8258(91)90268-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty-five patients with recurrent or advanced-stage endometrial cancer were treated with cisplatin, doxorubicin, and cyclophosphamide (PAC) from May 1982 to November 1987. A retrospective chart analysis was performed to evaluate the effect of treatment on survival and progression-free interval. Toxicity was moderate. Neutropenia was the most common side effect. Age, performance status, and tumor cytoreduction were statistically significant predictors of survival time (P < 0.03). In the 17 evaluable patients, the response rate was 47%. PAC is an active regimen in the treatment of endometrial cancer. Larger prospective studies are needed to evaluate whether tumor cytoreduction is important in the treatment of this disease. © 1991.

引用

页码：113 / 116

页数：4

共 23 条

[1] DOXORUBICIN CISPLATIN VINBLASTINE COMBINATION CHEMOTHERAPY OF ADVANCED ENDOMETRIAL CARCINOMA - A SOUTHWEST ONCOLOGY GROUP-STUDY [J].

ALBERTS, DS ;

MASON, NL ;

OTOOLE, RV ;

HILGERS, RD ;

RIVKIN, SE ;

BOUTSELIS, JG ;

PUGH, RP ;

VAITKEVICIUS, VK ;

GREEN, JB ;

OISHI, N .

GYNECOLOGIC ONCOLOGY, 1987, 26 (02) :193-201

[2]

COHEN CJ, 1986, CLIN OBSTET GYNAECOL, V13, P811

[3]

DEOLIVEIRA CF, 1986, P AN M AM SOC CLIN, V5, P123

[4] CHEMOTHERAPY OF ADVANCED AND RECURRENT ENDOMETRIAL CARCINOMA WITH CYCLOPHOSPHAMIDE, DOXORUBICIN, 5-FLUOROURACIL, AND MEGESTROL-ACETATE [J].

DEPPE, G ;

JACOBS, AJ ;

BRUCKNER, H ;

COHEN, CJ .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1981, 140 (03) :313-316

[5]

DISAIA PJ, 1989, CLIN GYNECOLOGIC ONC, P161

[6] RANDOMIZED PHASE II STUDIES OF CISPLATIN AND A COMBINATION OF CYCLOPHOSPHAMIDE DOXORUBICIN CISPLATIN (CAP) IN PATIENTS WITH PROGESTIN-REFRACTORY ADVANCED ENDOMETRIAL CARCINOMA [J].

EDMONSON, JH ;

KROOK, JE ;

HILTON, JF ;

MALKASIAN, GD ;

EVERSON, LK ;

JEFFERIES, JA ;

MAILLIARD, JA .

GYNECOLOGIC ONCOLOGY, 1987, 28 (01) :20-24

[7]

HACKER NF, 1983, OBSTET GYNECOL, V61, P413

[8]

HANCOCK KC, 1986, CANCER TREAT REP, V70, P789

[9] TREATMENT OF RECURRENT AND METASTATIC ENDOMETRIAL CANCER WITH CISPLATIN, DOXORUBICIN, CYCLOPHOSPHAMIDE, AND MEGESTROL-ACETATE [J].

HOFFMAN, MS ;

ROBERTS, WS ;

CAVANAGH, D ;

PRAPHAT, H ;

SOLOMON, P ;

LYMAN, GH .

GYNECOLOGIC ONCOLOGY, 1989, 35 (01) :75-77

[10]

HOMESLEY HD, 1989, J SURG ONCOL S, V1, P21

← 1 2 3 →