CYTOLOGICAL AND HISTOLOGICAL-CHANGES IN THE MIDDLE-EAR AFTER INOCULATION OF INFLUENZA-A VIRUS

被引：33

作者：

CHUNG, MH ^{[1
]}

GRIFFITH, SR ^{[1
]}

PARK, KH ^{[1
]}

LIM, DJ ^{[1
]}

DEMARIA, TF ^{[1
]}

机构：

[1] OHIO STATE UNIV, COLL MED,DEPT OTOLARYNGOL,OTOL RES LABS, 4331 UNIV HOSP CLIN,456 W 10TH AVE, COLUMBUS, OH 43210 USA

来源：

ACTA OTO-LARYNGOLOGICA | 1993年 / 113卷 / 01期

关键词：

OTITIS MEDIA; RESPIRATORY TRACT VIRUS; MIDDLE EAR; CILIATED CELLS; CHINCHILLA;

D O I：

10.3109/00016489309135771

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Experimental otitis media induced in the chinchilla by inoculation of influenza A virus into the middle ear resulted in capillary engorgement, subepithelial hemorrhage, tissue edema and acute inflammatory cell infiltration. Quantitative morphometric measurements were made for 28 days. Ciliated cells appeared to be the primary target of this strain of influenza virus and demonstrated the greatest degree of damage. Three weeks were required to restore the ciliated epithelium in the tubotympanum to normal levels.

引用

页码：81 / 87

页数：7

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