CATARACTS BY LIPID LOWERING DRUGS - 3 DIFFERENT HMG-COA REDUCTASE INHIBITORS STUDIED IN HYPERCHOLESTEROLEMIC RABBITS

被引：6

作者：

BEHRENSBAUMANN, W

THIERY, J

机构：

[1] UNIV MUNICH,KLINIKUM GROSSHADERN,INST CLIN CHEM,MARCHIONINISTR 15,W-8000 MUNICH 70,GERMANY

[2] UNIV GOTTINGEN,DEPT OPHTHALMOL,W-3400 GOTTINGEN,GERMANY

来源：

RESEARCH IN EXPERIMENTAL MEDICINE | 1992年 / 192卷 / 01期

关键词：

CATARACTS; HMG-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; RABBITS;

D O I：

10.1007/BF02576252

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We evaluated the effects of a lipid-lowering drug therapy with simvastatin, lovastatin, and pravastatin on the crystalline lens of the hypercholesterolemic rabbit. A threefold therapeutic dose was administered. Ocular examinations in mydriasis prior to treatment and after 14 and 30 weeks, respectively, were performed, including photographic documentation. Some degree of congenital lens opacities prior to treament was frequently observed. No development of new cataracts could be proved during the study period.

引用

页码：7 / 11

页数：5

共 16 条

[1] BEHRENSBAUMANN W, 1991, IN PRESS LENS EYE TO
[2] BEHRENSBAUMANN W, IN PRESS ARZNEIMITTE
[3] BISTNER SI, 1977, ATLAS VET OPHTHALMIC, P187
[4] FREUDIGER U, 1986, KLINIK HUNDEKRANKHEI, V1, P321
[5] ON THE ETIOLOGY OF SUBCAPSULAR LENTICULAR OPACITIES PRODUCED IN DOGS RECEIVING HMG-COA REDUCTASE INHIBITORS
GERSON, RJ
MACDONALD, JS
ALBERTS, AW
CHEN, J
YUDKOVITZ, JB
GREENSPAN, MD
RUBIN, LF
BOKELMAN, DL
[J]. EXPERIMENTAL EYE RESEARCH, 1990, 50 (01) : 65 - 78
[6] DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM
HAVEL, RJ
EDER, HA
BRAGDON, JH
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1955, 34 (09) : 1345 - 1353
[7] LOVASTATIN (MEVINOLIN) IN THE TREATMENT OF HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA - A MULTICENTER STUDY
HAVEL, RJ
HUNNINGHAKE, DB
ILLINGWORTH, DR
LEES, RS
STEIN, EA
TOBERT, JA
BACON, SR
BOLOGNESE, JA
FROST, PH
LAMKIN, GE
LEES, AM
LEON, AS
GARDNER, K
JOHNSON, G
MELLIES, MJ
RHYMER, PA
TUN, P
[J]. ANNALS OF INTERNAL MEDICINE, 1987, 107 (05) : 609 - 615
[8] LOVASTATIN - FOLLOW-UP OPHTHALMOLOGIC DATA
HUNNINGHAKE, DB
MILLER, VT
GOLDBERG, I
SCHONFELD, G
STEIN, EA
TOBERT, JA
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1988, 259 (03): : 354 - 355
[9] KIRBY TJ, 1967, T AM OPHTHAL SOC, V65, P493
[10] SATURATION AND SUPPRESSION OF HEPATIC LIPOPROTEIN RECEPTORS - A MECHANISM FOR THE HYPERCHOLESTEROLEMIA OF CHOLESTEROL-FED RABBITS
KOVANEN, PT
BROWN, MS
BASU, SK
BILHEIMER, DW
GOLDSTEIN, JL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (03): : 1396 - 1400

← 1 2 →