COMBINED EFFECTS OF SOLVENTS ON THE RATS AUDITORY-SYSTEM - STYRENE AND TRICHLOROETHYLENE

被引：22

作者：

REBERT, CS ^{[1
]}

BOYES, WK ^{[1
]}

PRYOR, GT ^{[1
]}

SVENSGAARD, DJ ^{[1
]}

KASSAY, KM ^{[1
]}

GORDON, GR ^{[1
]}

SHINSKY, N ^{[1
]}

机构：

[1] US EPA,HLTH EFFECTS RES LAB,RES TRIANGLE PK,NC 27711

来源：

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY | 1993年 / 14卷 / 01期

关键词：

SOLVENT; OTOTOXICITY; RAT; COMBINED EFFECT; INTERACTION;

D O I：

10.1016/0167-8760(93)90083-2

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Because exposures to toxic agents typically involve more than one substance, it is necessary to know if combined exposures pose different risks than those to single agents. Many solvents have been implicated in central nervous disorders and some of them are known to produce hearing loss, probably mediated by damage to cochlear hair cells. Hearing loss was studied by recording the brainstem auditory evoked response (BAER) in male Long Evans rats exposed 8 h/day for 5 days to mixtures of styrene (STY) and trichloroethylene (TCE). Dose groups included air or solvent pairs (STY/TCE) in the following concentrations (ppm): (0:3000), (250:2250), (500:1500), (750:750) and (1000:0). Decreased BAER amplitude, indicative of hearing loss, was correlated with blood levels of total solvent. The effects were as predicted by a linear dose-addition model, indicating neither synergistic nor antagonistic interactions at the concentrations studied.

引用

页码：49 / 59

页数：11

共 42 条

[1] NERVOUS-SYSTEM RESPONSES OF RATS TO SUBCHRONIC INHALATION OF N-HEXANE AND N-HEXANE+METHYL-ETHYL-KETONE MIXTURES
ALTENKIRCH, H
WAGNER, HM
STOLTENBURG, G
SPENCER, PS
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1982, 57 (2-3) : 209 - 219
[2] ARLIENSOBORG P, 1992, SOLVENT NEUROTOXICIT
[3] *ATSDR, 1989, BIENN REP C, V2
[4] BERENBAUM MC, 1989, PHARMACOL REV, V41, P93
[5] CRITERIA FOR ANALYZING INTERACTIONS BETWEEN BIOLOGICALLY-ACTIVE AGENTS
BERENBAUM, MC
[J]. ADVANCES IN CANCER RESEARCH, 1981, 35 : 269 - 335
[6] CALABRESE EJ, 1991, MULTIPLE CHEM INTERA
[7] CRANMER JM, 1986, NEUROTOXICOLOGY, V7, P5
[8] GIBSON WPR, 1978, ESSENTIALS CLIN ELEC
[9] HAIDER M, 1989, ARCH COMPLEX ENV STU, V1, P7
[10] IKEDA M, 1978, SCAND J WORK ENV HEA, V2, P41

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