CENTRAL ALPHA(2)-ADRENOCEPTOR-MEDIATED INHIBITION OF GASTRIC-MOTILITY IN RATS

被引：10

作者：

NAGATA, M

OSUMI, Y

机构：

[1] Department of Pharmacology, Kochi Medical School, Nankoku

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1993年 / 62卷 / 03期

关键词：

CENTRAL ALPHA-ADRENOCEPTOR; GASTRIC MOTILITY;

D O I：

10.1254/jjp.62.329

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the subtype of alpha-adrenoceptors participating in central noradrenergic inhibition of gastric motility in urethane-anesthetized rats. Noradrenaline at 10 nmole administered intracisternally (i.c.) significantly decreased gastric motility. Yohimbine at 10 nmole, i.c., but not the same dose of prazosin, abolished this noradrenaline-induced decrease in gastric motility. Clonidine at 10 nmole, i.c., but not phenylephrine at 20 nmole, significantly decreased gastric motility. These results suggest that alpha2-adrenoceptor-mediated mechanisms in the brain stem are involved in noradrenergic inhibitory regulation of gastric motility.

引用

页码：329 / 330

页数：2

共 9 条

[1]

BERNARDINI C, 1986, ARCH INT PHARMACOD T, V281, P134

[2] EFFECTS OF INTRA-VENTRICULAR ANGIOTENSIN-II MEDIATED BY SYMPATHETIC NERVOUS-SYSTEM [J].