THE ACTIVITY OF HYDROXYNAPHTHOQUINONES AGAINST LEISHMANIA-DONOVANI

被引：80

作者：

CROFT, SL ^{[1
]}

HOGG, J ^{[1
]}

GUTTERIDGE, WE ^{[1
]}

HUDSON, AT ^{[1
]}

RANDALL, AW ^{[1
]}

机构：

[1] WELLCOME RES LABS, BECKENHAM BR3 3BS, KENT, ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1992年 / 30卷 / 06期

关键词：

D O I：

10.1093/jac/30.6.827

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The hydroxynaphthoquinoncs, buparvaquone, 250C80 and 56W82, showed high activity in vitro against Leishmania donovani amastigotes in mouse peritoneal macro phages, with ED50 values of 0-05, 2·95 and 13·82 μM, respectively. Fourteen other hydroxynaphthoquinones were tested, of which only 566C80 and 608C86 showed significant activity against amastigotes. Buparvaquone, 250C80 and 56W82 were also highly-active against cultured promastigotes. In a BALB/c mouse model, treatment with 100 mg/kg/day for five days with buparvaquone, 250C80 and 566C80 (atovaquone) reduced liver amastigote numbers by 60%, 22% and 30·5%, respectively. © 1992 The British Society for Antimicrobial Chemotherapy.

引用

页码：827 / 832

页数：6

共 18 条

[1] REMARKABLE INVITRO AND INVIVO ACTIVITIES OF THE HYDROXYNAPHTHOQUINONE 566C80 AGAINST TACHYZOITES AND TISSUE CYSTS OF TOXOPLASMA-GONDII [J].