INACTIVATION OF SIMIAN IMMUNODEFICIENCY VIRUS BY HYDROSTATIC-PRESSURE

被引：55

作者：

JURKIEWICZ, E

BILLASBOAS, M

SILVA, JL

WEBER, G

HUNSMANN, G

CLEGG, RM

机构：

[1] UNIV FED RIO DE JANEIRO,DEPT BIOQUIM MED,BR-21945 RIO JANEIRO,BRAZIL

[2] UNIV ILLINOIS,SCH CHEM SCI,DEPT BIOCHEM,URBANA,IL 61801

[3] MAX PLANCK INST BIOPHYS CHEM,MOLEK BIOL ABT,D-37077 GOTTINGEN,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 15期

关键词：

RETROVIRUS INACTIVATION; PRESSURE INACTIVATION;

D O I：

10.1073/pnas.92.15.6935

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The inactivation of the simian immunodeficiency viruses SIVmac251 and SIVagm by pressures of 150 and 250 MPa was determined. The extent of inactivation depended on the time that the virus was subjected to compression as well as the level of the pressure and at 150 Mpa reached 5 log(10) dilution units after approximate to 10 hr. The inactivations, which were uniformly carried out at room temperature, were independent of the concentration of the virus. Possible applications of pressure inactivation for molecular biological and clinical use are discussed.

引用

页码：6935 / 6937

页数：3

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