ORIGIN OF HIGH-GRADE LYMPHOMAS IN RICHTER SYNDROME

被引：19

作者：

BESSUDO, A ^{[1
]}

KIPPS, TJ ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,DIV HEMATOL ONCOL,LA JOLLA,CA 92093

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 5-6期

关键词：

ORIGIN HIGH GRADE LYMPHOMA; RICHTER SYNDROME;

D O I：

10.3109/10428199509059634

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with B cell chronic lymphocytic leukemia (CLL) occasionally develop high-grade B cell lymphomas that are associated with constitutional symptoms, rapidly progressive lymphadenopathy, and swift clinical deterioration. Now known as Richter syndrome, this symptom complex develops in approximately 5% of all patients with CLL. Structural and molecular analysis of the immunoglobulin (Ig) genes have allowed investigators to define the clonal relationship between the leukemia and lymphoma cells of a given patient. In most cases the aggressive lymphoma evolves from the original leukemia cell clone. However, in some cases the lymphoma apparently represents a second malignancy. Differentiation between these two types of lymphoma may have clinical significance, Further investigation is required to allow for identification of CLL patients who are at risk for developing Richter syndrome and to understand factors involved in its etiopathogenesis.

引用

页码：367 / 372

页数：6

共 59 条

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