INHIBITION OF HIPPOCAMPO-PREFRONTAL CORTEX EXCITATORY RESPONSES BY THE MESOCORTICAL DA SYSTEM

被引：67

作者：

JAY, TM ^{[1
]}

GLOWINSKI, J ^{[1
]}

THIERRY, AM ^{[1
]}

机构：

[1] COLL FRANCE,INSERM,U114,F-75231 PARIS 05,FRANCE

来源：

NEUROREPORT | 1995年 / 6卷 / 14期

关键词：

VENTRAL TEGMENTAL AREA; DOPAMINE; EXCITATORY AMINO ACID; HIPPOCAMPUS; PREFRONTAL CORTEX;

D O I：

10.1097/00001756-199510020-00006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE prefrontal cortex (PFC) receives dopaminergic (DA) afferents from the ventral tegmental area (VTA) and excitatory inputs from the hippocampal formation. The present electrophysiological experiments performed in anaesthetized rats demonstrate that activation of the mesocortical DA system blocked the spontaneous activity of PFC neurones and the excitatory responses induced by hippocampal stimulation. These data indicate that there is a convergence in the effects of hippocampal and DA mesocortical afferents on common PFC neurones. Furthermore, a population of PFC neurones responding to hippocampal stimulation could be identified as projecting to either the nucleus accumbens and/or the VTA, suggesting that the hippocampus exerts an indirect influence on these two structures through the PFC.

引用

页码：1845 / 1848

页数：4

共 26 条

[1]

BERENDSE HW, 1992, J COMP NEUROL, V316, P214

[2] HISTOCHEMICAL CONFIRMATION FOR DOPAMINERGIC INNERVATION OF RAT CEREBRAL-CORTEX AFTER DESTRUCTION OF NORADRENERGIC ASCENDING PATHWAYS [J].